PMID- 10078316
OWN - NLM
STAT- MEDLINE
DCOM- 19990504
LR  - 20191103
IS  - 0394-9532 (Print)
IS  - 0394-9532 (Linking)
VI  - 10
IP  - 6
DP  - 1998 Dec
TI  - Effects of caloric restriction or augmentation in adult rats: longevity and 
      lesion biomarkers of aging.
PG  - 463-70
AB  - Caloric restriction (CR) initiated in young rodents has been thoroughly 
      documented to enhance longevity, but its efficacy when introduced at older ages 
      has not been well investigated. Cohorts of 18- and 26-month-old male F344 x BN F1 
      hybrid rats were fed either: 1) NIH-31 meal (C); 2) vitamin and mineral fortified 
      NIH-31 meal (R); or 3) vitamin and mineral fortified NIH-31 meal supplemented 
      with corn oil and sweetened condensed milk (S). The C control rats were fed ad 
      libitum, R rats were restricted to 32% of the caloric intake of the controls, and 
      S rats were allowed to consume not more than 8% more calories than C rats. After 
      6 weeks, the average weights were significantly different between all diet and 
      age groups. Although calorie manipulation altered body weight, no significant 
      effect of the dietary intervention on longevity was found. The average lesion 
      burden, including tumor burden and prevalence of nearly all commonly occurring 
      lesions, were comparable between the groups. Thus, the manipulation of weight at 
      ages beyond middle age has a much less profound impact than similar interventions 
      during growth and maturation in rats.
FAU - Lipman, R D
AU  - Lipman RD
AD  - Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 
      Boston, Massachusetts 02111, USA.
FAU - Smith, D E
AU  - Smith DE
FAU - Blumberg, J B
AU  - Blumberg JB
FAU - Bronson, R T
AU  - Bronson RT
LA  - eng
GR  - AG07747/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Italy
TA  - Aging (Milano)
JT  - Aging (Milan, Italy)
JID - 9102503
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adrenal Gland Neoplasms/epidemiology/pathology
MH  - Aging/metabolism/*physiology
MH  - Animals
MH  - Biomarkers
MH  - Blood Glucose/analysis
MH  - Body Weight/physiology
MH  - *Energy Intake
MH  - *Food, Fortified
MH  - *Longevity
MH  - Male
MH  - Pheochromocytoma/epidemiology/pathology
MH  - Prevalence
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - 10.1007/BF03340160 [doi]
PST - ppublish
SO  - Aging (Milano). 1998 Dec;10(6):463-70. doi: 10.1007/BF03340160.