PMID- 10078332
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20191103
IS  - 0939-4451 (Print)
IS  - 0939-4451 (Linking)
VI  - 16
IP  - 1
DP  - 1999
TI  - Contribution of serum albumin to the transport of orally administered 
      L-tryptophan into liver of rats with L-tryptophan depletion.
PG  - 29-39
AB  - The role of serum albumin in the transport of orally administered L-tryptophan 
      (Trp) into rat tissues was examined using analbuminemic and Sprague-Dawley (SD) 
      rats with and without alpha-methyl-DL-tryptophan (AMT)-induced Trp depletion. Trp 
      was orally administered to rats 16 h after AMT or 0.85% NaCl administration, when 
      liver tryptophan 2,3-dioxygenase and protein synthetic activities in AMT-treated 
      rats were similar to those of 0.85% NaCl-treated rats. After oral Trp 
      administration, regardless of the presence or absence of Trp depletion, free 
      serum Trp concentrations were similar in the analbuminemic and SD rats, while 
      total serum Trp concentrations were lower in analbuminemic rats than in SD rats. 
      Although liver, brain, and muscle Trp concentrations after oral Trp 
      administration under Trp depletion were lower in analbuminemic rats than in SD 
      rats, the ratio of the liver Trp concentration in analbuminemic rats to that in 
      SD rats was smaller than that of the brain or muscle Trp concentration. These 
      results suggest that variations in serum albumin levels could affect the 
      transport of orally administered Trp into the liver of rats with Trp depletion.
FAU - Sasaki, E
AU  - Sasaki E
AD  - Department of Biochemistry, School of Medicine, Fujita Health University, 
      Toyoake, Japan.
FAU - Ohta, Y
AU  - Ohta Y
FAU - Shinohara, R
AU  - Shinohara R
FAU - Ishiguro, I
AU  - Ishiguro I
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Amino Acids)
RN  - 0 (Serum Albumin)
RN  - 8DUH1N11BX (Tryptophan)
RN  - EC 1.13.11.11 (Tryptophan Oxygenase)
SB  - IM
MH  - Administration, Oral
MH  - Amino Acids/blood
MH  - Animals
MH  - Biological Transport
MH  - Blood Protein Disorders/*metabolism
MH  - Brain/metabolism
MH  - Kidney/metabolism
MH  - Liver/enzymology/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serum Albumin/*metabolism
MH  - Tissue Distribution
MH  - Tryptophan/blood/deficiency/*pharmacokinetics
MH  - Tryptophan Oxygenase/metabolism
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - 10.1007/BF01318883 [doi]
PST - ppublish
SO  - Amino Acids. 1999;16(1):29-39. doi: 10.1007/BF01318883.