PMID- 10078848
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20210430
VI  - 23
IP  - 2
DP  - 1999 Feb
TI  - Leptin and total cholesterol are predictors of weight gain in pre-pubertal 
      children.
PG  - 146-50
AB  - OBJECTIVE: The aim of this study was to identify specifically which biochemical 
      indices predict excessive weight gain over time in a cohort of pre-pubertal 
      children. SUBJECTS: Fifty nine healthy pre-pubertal children (age: 6.3-9.8y). 
      MEASUREMENTS: Children were defined anthropometrically and biochemically at 
      baseline. Height and weight measurements were then repeated after six (n=52) and 
      12 months (n=37). RESULTS: Weight change after six months (defined by a change in 
      body mass index (BMI) z-score from baseline) demonstrated no correlation with 
      fasting plasma levels of leptin, insulin, insulin:glucose (IG) ratio, 
      cholesterol, triglyceride or high density lipoprotein (HDL) cholesterol. However, 
      after 12 months there was a significant negative correlation between BMI z-score 
      change and initial plasma leptin (r=-0.35, P=0.048) and this relationship 
      strengthened when adjusted for body fat (from bio-electrical impedance; r=-0.46, 
      P=0.009). In addition, there was a significant positive relationship between 
      plasma total cholesterol and BMI z score change (r=0.38, P=0.03) and this 
      relationship remained unchanged when adjusted for body fat. No relationship was 
      observed between weight change after 12 months and plasma levels of insulin, IG 
      ratio, HDL cholesterol or triglyceride. CONCLUSION: Plasma leptin and total 
      cholesterol were found to be predictive of weight gain over 12 months in a cohort 
      of pre-pubertal children. These two potential predictors can be readily measured 
      in clinical practice and these findings may represent a method of defining the 
      'at risk of obesity' state in childhood.
FAU - Byrnes, S E
AU  - Byrnes SE
AD  - Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown NSW, 
      Australia.
FAU - Baur, L A
AU  - Baur LA
FAU - Bermingham, M
AU  - Bermingham M
FAU - Brock, K
AU  - Brock K
FAU - Steinbeck, K
AU  - Steinbeck K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Obes Relat Metab Disord
JT  - International journal of obesity and related metabolic disorders : journal of the 
      International Association for the Study of Obesity
JID - 9313169
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Proteins)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Anthropometry
MH  - Body Mass Index
MH  - Child
MH  - Cholesterol/*blood
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Leptin
MH  - Male
MH  - Obesity/*blood/prevention & control
MH  - Predictive Value of Tests
MH  - Proteins/*metabolism
MH  - Puberty
MH  - Sex Characteristics
MH  - Weight Gain/*physiology
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - 10.1038/sj.ijo.0800783 [doi]
PST - ppublish
SO  - Int J Obes Relat Metab Disord. 1999 Feb;23(2):146-50. doi: 
      10.1038/sj.ijo.0800783.