PMID- 10079383
OWN - NLM
STAT- MEDLINE
DCOM- 19990708
LR  - 20191103
IS  - 1219-4956 (Print)
IS  - 1219-4956 (Linking)
VI  - 5
IP  - 1
DP  - 1999
TI  - Human herpesvirus 8 in hematologic diseases.
PG  - 73-9
AB  - Human herpesvirus type 8 (HHV-8), also known as Kaposi's sarcoma-associated 
      herpesvirus (KSHV) is a new member of the g-herpesvirus family. It is an unusual 
      herpesvirus in that it carries a large number of genes that encode oncoproteins 
      or cell signaling proteins. In addition to being the causative agent of both 
      HIV-associated and non-HIV-associated Kaposi's sarcoma this DNA tumor virus has 
      been implicated in the pathogenesis of several diseases. These include multiple 
      myeloma (MM), Waldenstom's macroglobulinemia (WM), multicentric Castleman's 
      disease (MCD), body cavity-based lymphoma (BCBL), and various other conditions 
      such as sarcoidosis and pemphigus. While the causative role of the viral 
      infection is fairly certain in the development of BCBL and multicentric 
      Castleman's disease, HHV-8 may act through a different mechanism to induce plasma 
      cell malignancies. It has been suggested though the finding is still 
      controversial - that infection of bone marrow stromal dendritic cells by HHV-8 
      might be a key factor in the etiology and pathogenesis of monoclonal 
      gammopathies. The aim of this review is to provide a short introduction into the 
      tumorigenic potential of HHV-8 as well as to detail the available data and 
      possible mechanisms on the involvement of this virus in different hematologic 
      diseases.
FAU - Mikala, G
AU  - Mikala G
AD  - Imre Haynal University of Health Sciences, First Department of Internal Medicine, 
      Budapest, Hungary.
FAU - Xie, J
AU  - Xie J
FAU - Berencsi, G
AU  - Berencsi G
FAU - Kiss, C
AU  - Kiss C
FAU - Marton, I
AU  - Marton I
FAU - Domjan, G
AU  - Domjan G
FAU - Valyi-Nagy, I
AU  - Valyi-Nagy I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
SB  - IM
MH  - Bone Marrow/virology
MH  - Castleman Disease/virology
MH  - Dendritic Cells/virology
MH  - Hematologic Diseases/*virology
MH  - Hematologic Neoplasms/virology
MH  - Herpesviridae Infections/complications/*virology
MH  - Herpesvirus 8, Human/genetics/*isolation & purification/pathogenicity
MH  - Humans
MH  - Lymphoma, AIDS-Related/virology
MH  - Lymphoma, Non-Hodgkin/virology
MH  - Multiple Myeloma/virology
MH  - Oncogenes
MH  - Plasma Cells/pathology
MH  - Sarcoma, Kaposi/etiology/virology
MH  - Stromal Cells/virology
MH  - Tumor Virus Infections/complications/*virology
MH  - Waldenstrom Macroglobulinemia/virology
RF  - 42
EDAT- 1999/03/18 00:00
MHDA- 1999/03/18 00:01
CRDT- 1999/03/18 00:00
PHST- 1999/03/18 00:00 [pubmed]
PHST- 1999/03/18 00:01 [medline]
PHST- 1999/03/18 00:00 [entrez]
AID - 10.1053/paor.1999.0073 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 1999;5(1):73-9. doi: 10.1053/paor.1999.0073.