PMID- 10080220
OWN - NLM
STAT- MEDLINE
DCOM- 19990318
LR  - 20220309
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 106
IP  - 3
DP  - 1999 Mar
TI  - Pars planitis: clinical features and class II HLA associations.
PG  - 594-9
AB  - OBJECTIVE: To describe a cohort of patients with pars planitis followed at a 
      single tertiary care institution, determine the frequency of multiple sclerosis 
      and/or optic neuritis in patients with this disorder, and calculate gene 
      frequencies of human leukocyte antigen (HLA) class II alleles in these patients. 
      DESIGN: Fifty-three patients with the diagnosis of pars planitis underwent 
      clinical record review or telephone interview for follow-up or both; 32 of these 
      underwent phlebotomy for analysis of HLA class II alleles. MAIN OUTCOME MEASURES: 
      Outcomes included visual acuity, occurrence of multiple sclerosis and/or optic 
      neuritis, and HLA class II gene frequencies. RESULTS: With a mean follow-up of 2 
      years, approximately 90% of patients maintained a visual acuity better than 20/40 
      in at least one eye. The most frequently encountered ophthalmic complications 
      included cystoid macular edema, cataract, and epiretinal membrane formation. Of 
      37 patients with pars planitis who had medical or neurologic follow-up 
      evaluations, 6 (16.2%) developed multiple sclerosis. The HLA-DR15 allele, coding 
      for one of the two HLA-DR2 subtypes, was associated with pars planitis (odds 
      ratio = 2.86, 95% confidence interval = 1.42-5.78, P = 0.004). CONCLUSIONS: A 
      common immunogenetic predisposition to multiple sclerosis and pars planitis may 
      be associated with the HLA-DR15 allele. This association may represent genetic 
      linkage to the HLA-DR locus or a role for the HLA-DR15 gene product in the 
      pathogenesis of both of these diseases.
FAU - Raja, S C
AU  - Raja SC
AD  - Department of Ophthalmology, Johns Hopkins University School of Medicine, 
      Baltimore, Maryland, USA.
FAU - Jabs, D A
AU  - Jabs DA
FAU - Dunn, J P
AU  - Dunn JP
FAU - Fekrat, S
AU  - Fekrat S
FAU - Machan, C H
AU  - Machan CH
FAU - Marsh, M J
AU  - Marsh MJ
FAU - Bressler, N M
AU  - Bressler NM
LA  - eng
GR  - EY 01765/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR15 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Frequency
MH  - Genetic Linkage/genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR Serological Subtypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis/genetics
MH  - Optic Neuritis/diagnosis/genetics
MH  - Pars Planitis/*diagnosis/*genetics
MH  - Prognosis
MH  - Visual Acuity
EDAT- 1999/03/18 00:00
MHDA- 1999/03/18 00:01
CRDT- 1999/03/18 00:00
PHST- 1999/03/18 00:00 [pubmed]
PHST- 1999/03/18 00:01 [medline]
PHST- 1999/03/18 00:00 [entrez]
AID - S0161-6420(99)90122-7 [pii]
AID - 10.1016/S0161-6420(99)90122-7 [doi]
PST - ppublish
SO  - Ophthalmology. 1999 Mar;106(3):594-9. doi: 10.1016/S0161-6420(99)90122-7.