PMID- 10080385
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20220310
IS  - 0301-0082 (Print)
IS  - 0301-0082 (Linking)
VI  - 57
IP  - 4
DP  - 1999 Feb
TI  - Distribution and retrograde transport of trophic factors in the central nervous 
      system: functional implications for the treatment of neurodegenerative diseases.
PG  - 451-84
AB  - Neurotrophins play a crucial role in the maintenance, survival and selective 
      vulnerability of various neuronal populations within the normal and diseased 
      brain. Several families of growth promoting substances have been identified 
      within the central nervous system (CNS) including the superfamily of nerve growth 
      factor related neurotrophin factors, glial derived neurotrophic factor (GDNF) and 
      ciliary neurotrophic factor (CNTF). In addition, other non-neuronal growth 
      factors such as fibroblast growth factor (FGF) have also been identified. This 
      article reviews the trophic anatomy of these factors within the CNS. 
      Intraventricular and intraparenchymal injections of exogenous nerve growth factor 
      result in retrograde labeling mainly within the cholinergic basal forebrain. 
      Distribution of brain derived neurotrophic factor (BDNF) following 
      intraventricular injection is minimal due to the binding to the trkB receptor 
      along the ventricular wall. In contrast, intraparenchymal injections of BDNF 
      results in widespread retrograde transport throughout the CNS. BDNF has also been 
      shown to be transported anterogradely within the CNS. Infusion of GDNF into the 
      CNS results in retrograde transport limited to the nigrostriatal pathway. 
      Hippocampal injections of NT-3 retrogradely label mainly basal forebrain neurons. 
      Retrograde transport of radiolabeled CNTF has only been observed in sensory 
      neurons of the sciatic nerve. Following intraventricular and intraparenchymal 
      infusion of radiolabeled bFGF, retrograde neuronal labeling was found in the 
      telecephalon, diencephalon, mesencephalon and pons. In contrast retrograde 
      labeling for aFGF was found only in the hypothalamus and midbrain. Since select 
      neurotrophins traffic anterogradely and retrogradely within the nervous system, 
      these proteins could be used to treat neurological diseases such as Alzheimer's 
      disease, Parkinson's disease and amyotrophic lateral sclerosis.
FAU - Mufson, E J
AU  - Mufson EJ
AD  - Research Center for Brain Repair, Department of Neurological Sciences, Rush 
      Presbyterian-Luke's Medical Center, Chicago, IL 60612, USA. emufson@rush.edu
FAU - Kroin, J S
AU  - Kroin JS
FAU - Sendera, T J
AU  - Sendera TJ
FAU - Sobreviela, T
AU  - Sobreviela T
LA  - eng
GR  - AG09466/AG/NIA NIH HHS/United States
GR  - AG10161/AG/NIA NIH HHS/United States
GR  - AG10668/AG/NIA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Prog Neurobiol
JT  - Progress in neurobiology
JID - 0370121
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Animals
MH  - *Axonal Transport
MH  - Central Nervous System/cytology/*metabolism/pathology
MH  - Fibroblast Growth Factors/administration & dosage/metabolism
MH  - Humans
MH  - Nerve Growth Factors/administration & dosage/*metabolism/pharmacology
MH  - Nerve Tissue Proteins/administration & dosage/*metabolism/pharmacology
MH  - Neurodegenerative Diseases/metabolism/*therapy
MH  - Receptors, Nerve Growth Factor/metabolism
RF  - 204
EDAT- 1999/03/18 00:00
MHDA- 1999/03/18 00:01
CRDT- 1999/03/18 00:00
PHST- 1999/03/18 00:00 [pubmed]
PHST- 1999/03/18 00:01 [medline]
PHST- 1999/03/18 00:00 [entrez]
AID - S0301-0082(98)00059-8 [pii]
AID - 10.1016/s0301-0082(98)00059-8 [doi]
PST - ppublish
SO  - Prog Neurobiol. 1999 Feb;57(4):451-84. doi: 10.1016/s0301-0082(98)00059-8.