PMID- 10081916
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 261
IP  - 1-2
DP  - 1999 Feb 12
TI  - Evidence for up-regulation of brain-derived neurotrophic factor mRNA by soy 
      phytoestrogens in the frontal cortex of retired breeder female rats.
PG  - 17-20
AB  - In this study, we examined the effects of oral micronized estradiol and soy 
      phytoestrogens on the mRNA levels of brain-derived neurotrophic factor (BDNF) in 
      the frontal cortex of ovariectomized retired breeder female rats. Fifteen 
      ovariectomized rats were randomized into three groups and fed either a soy-free 
      control diet (OVX), a control diet with added soybean estrogens (SBE), or a 
      control diet with added estradiol (E2) for 8 weeks. Frontal cortex samples were 
      collected for RNA isolation. Northern and Phosphorlmager analyses were used to 
      determine the relative levels of BDNF mRNA. Both estradiol and soy phytoestrogens 
      significantly increased the mRNA levels of BDNF compared to ovariectomized 
      controls, suggesting that soy phytoestrogens may act as estrogen agonists in 
      regulating BDNF mRNA in the frontal cortex of retired breeder female rats.
FAU - Pan, Y
AU  - Pan Y
AD  - Comparative Medicine Clinical Research Center, Wake Forest University School of 
      Medicine, Winston-Salem, NC 27157-1040, USA. ypan@cpm.bgsm.edu
FAU - Anthony, M
AU  - Anthony M
FAU - Clarkson, T B
AU  - Clarkson TB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Actins)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Probes)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Isoflavones)
RN  - 0 (Phosphorus Radioisotopes)
RN  - 0 (Phytoestrogens)
RN  - 0 (Plant Preparations)
RN  - 0 (RNA, Messenger)
RN  - 0 (Soybean Proteins)
SB  - IM
MH  - Actins/genetics
MH  - Age Factors
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cognition/physiology
MH  - DNA Probes
MH  - Estrogens, Non-Steroidal/*pharmacology
MH  - Female
MH  - Frontal Lobe/chemistry/drug effects/*metabolism
MH  - *Isoflavones
MH  - Ovariectomy
MH  - Phosphorus Radioisotopes
MH  - Phytoestrogens
MH  - Plant Preparations
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Soybean Proteins/*pharmacology
EDAT- 1999/03/19 00:00
MHDA- 1999/03/19 00:01
CRDT- 1999/03/19 00:00
PHST- 1999/03/19 00:00 [pubmed]
PHST- 1999/03/19 00:01 [medline]
PHST- 1999/03/19 00:00 [entrez]
AID - S0304-3940(98)00994-X [pii]
AID - 10.1016/s0304-3940(98)00994-x [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Feb 12;261(1-2):17-20. doi: 10.1016/s0304-3940(98)00994-x.