PMID- 10081934
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 261
IP  - 1-2
DP  - 1999 Feb 12
TI  - A serotonin-1A receptor agonist and an N-methyl-D-aspartate receptor antagonist 
      oppose each others effects in a genetic rat epilepsy model.
PG  - 89-92
AB  - The WAG/RIJ rats exhibit spontaneously occurring spike-wave discharges (SWD) 
      accompanied by behavioural phenomena, with characteristics similar to the human 
      absence type epilepsy. To study the mechanisms involved in this type of 
      epileptiform activity we investigated the effects of the serotonin-1A (5-HT1A) 
      receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and the 
      N-methyl-D-aspartate (NMDA) receptor antagonist 
      (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine maleate 
      (MK-801). Intracerebroventricular (i.c.v.) injection of 8-OH-DPAT caused marked, 
      dose dependent increase, MK-801 a decrease in the cumulative duration and number 
      of spike-wave discharges. Pretreatment with MK-801 (10 microg/rat i.c.v.) 
      abolished the increase caused by 8-OH-DPAT (20 microg/rat i.c.v.), but the 
      decrease in SWD to MK-801 was counterbalanced by 8-OH-DPAT. These data provide 
      evidence for an interaction of glutamatergic and serotonergic mechanisms in the 
      triggering and maintenance of epileptic activity in this genetic model of absence 
      epilepsy.
FAU - Filakovszky, J
AU  - Filakovszky J
AD  - Laboratory of Neurochemistry and Experimental Medicine, National Institute of 
      Psychiatry and Neurology, Budapest, Hungary.
FAU - Gerber, K
AU  - Gerber K
FAU - Bagdy, G
AU  - Bagdy G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Receptors, Serotonin, 5-HT1)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/*pharmacology
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Brain Chemistry/physiology
MH  - Disease Models, Animal
MH  - Dizocilpine Maleate/*pharmacology
MH  - Epilepsy, Absence/drug therapy/genetics/*physiopathology
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, N-Methyl-D-Aspartate/*physiology
MH  - Receptors, Serotonin/*physiology
MH  - Receptors, Serotonin, 5-HT1
MH  - Serotonin Receptor Agonists/*pharmacology
EDAT- 1999/03/19 00:00
MHDA- 1999/03/19 00:01
CRDT- 1999/03/19 00:00
PHST- 1999/03/19 00:00 [pubmed]
PHST- 1999/03/19 00:01 [medline]
PHST- 1999/03/19 00:00 [entrez]
AID - S0304-3940(99)00015-4 [pii]
AID - 10.1016/s0304-3940(99)00015-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Feb 12;261(1-2):89-92. doi: 10.1016/s0304-3940(99)00015-4.