PMID- 10081971
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 261
IP  - 3
DP  - 1999 Feb 19
TI  - Peripheral projections of primary sensory neurons immunoreactive for 
      brain-derived neurotrophic factor.
PG  - 151-4
AB  - Brain-derived neurotrophic factor (BDNF) is synthesized in a subpopulation of 
      primary sensory neurons and transported anterogradely to the spinal cord and 
      peripheral targets. In the present study, the peripheral projection of sensory 
      neurons immunoreactive (-ir) for BDNF was examined by a combined method of 
      immunohistochemistry and retrograde tracing in rats. It was found that 36.3% of 
      sensory neurons projecting to subcutaneous tissues, 9.8% to epidermis and 8.3% to 
      muscle, contained BDNF immunoreactivity. In contrast, only 0.2% of sensory 
      neurons projecting to adrenal gland and 0.9% to coeliac ganglia contained BDNF. A 
      small proportion of sensory neurons projecting to muscles, mesenteric blood 
      vessels and hair follicles was also BDNF immunoreactive. These results provide 
      evidence that primary sensory neurons immunoreactive for BDNF project mainly to 
      subcutaneous tissues but not to autonomic ganglia and their adjacent viscera.
FAU - Zhou, X F
AU  - Zhou XF
AD  - Department of Human Physiology and Center for Neuroscience, Flinders University 
      of South Australia, Adelaide, Australia. pzxfz@cc.flinders.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Stilbamidines)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Fluorescent Dyes
MH  - Ganglia, Sympathetic/cytology/metabolism
MH  - Hair Follicle/innervation/metabolism
MH  - Immunohistochemistry
MH  - Mesenteric Veins/innervation
MH  - Muscle, Skeletal/innervation
MH  - Neurons, Afferent/metabolism/*physiology
MH  - Peripheral Nerves/cytology/metabolism/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/innervation
MH  - Spinal Cord/metabolism
MH  - *Stilbamidines
EDAT- 1999/03/19 00:00
MHDA- 1999/03/19 00:01
CRDT- 1999/03/19 00:00
PHST- 1999/03/19 00:00 [pubmed]
PHST- 1999/03/19 00:01 [medline]
PHST- 1999/03/19 00:00 [entrez]
AID - S0304394099000245 [pii]
AID - 10.1016/s0304-3940(99)00024-5 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Feb 19;261(3):151-4. doi: 10.1016/s0304-3940(99)00024-5.