PMID- 10082250
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20190909
IS  - 0387-7604 (Print)
IS  - 0387-7604 (Linking)
VI  - 21
IP  - 1
DP  - 1999 Jan
TI  - Developmental expression of monocyte chemoattractant protein-1 in the human 
      cerebellum and brainstem.
PG  - 30-5
AB  - The developmental expression of monocyte chemoattractant protein-1 (MCP-1) in the 
      cerebellum, medulla oblongata and pons was investigated in 26 normal human 
      brains, ranging from 20 weeks of gestation (GW) to adulthood by means of an 
      immunohistochemical method. Immunoreactivity to MCP-1 was observed in neurons of 
      the cerebellum and brainstem, and was mainly distributed in the cytoplasm and 
      dendrites. MCP-1-positive Purkinje cells appeared at 27 GW, reached a peak at 36 
      GW, and then decreased after 1 month of age, almost completely disappearing by 
      1-2 years of age. MCP-1-reactive neurons in the dentate nucleus and inferior 
      olivary nucleus showed temporal increases similar to that of Purkinje cells. In 
      the pons, however, MCP-1 reactivity was low in neurons of the pontine nuclei 
      persisting from the fetal to the adult period, and was very low and short in the 
      reticular formation and cranial nerve nuclei during the fetal and/or neonatal 
      period. MCP-1 Western blotting of the cerebellar cortex confirmed the specificity 
      of the immunohistochemistry. Our results suggest that MCP-1 may be related to the 
      maturation of Purkinje cells, the dentate nucleus, the inferior olivary nucleus, 
      and their network, promoting the growth of dendrites and synapses. Furthermore, 
      MCP-1 may also be useful for the study of abnormal neuron development and 
      ischemic damage.
FAU - Meng, S Z
AU  - Meng SZ
AD  - Department of Mental Retardation and Birth Defect Research, National Institute of 
      Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
FAU - Oka, A
AU  - Oka A
FAU - Takashima, S
AU  - Takashima S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aging/*metabolism
MH  - Blotting, Western
MH  - Brain Stem/embryology/*metabolism
MH  - Cerebellum/embryology/*metabolism
MH  - Chemokine CCL2/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Embryonic and Fetal Development/physiology
MH  - Fetus/*metabolism/physiology
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Infant, Newborn
MH  - Medulla Oblongata/embryology/metabolism
MH  - Pons/embryology/metabolism
MH  - Tissue Distribution/physiology
EDAT- 1999/03/19 00:00
MHDA- 1999/03/19 00:01
CRDT- 1999/03/19 00:00
PHST- 1999/03/19 00:00 [pubmed]
PHST- 1999/03/19 00:01 [medline]
PHST- 1999/03/19 00:00 [entrez]
AID - S0387760498000655 [pii]
AID - 10.1016/s0387-7604(98)00065-5 [doi]
PST - ppublish
SO  - Brain Dev. 1999 Jan;21(1):30-5. doi: 10.1016/s0387-7604(98)00065-5.