PMID- 10082400
OWN - NLM
STAT- MEDLINE
DCOM- 19990630
LR  - 20190909
IS  - 0303-6987 (Print)
IS  - 0303-6987 (Linking)
VI  - 26
IP  - 2
DP  - 1999 Feb
TI  - Lichenoid and subacute cutaneous lupus erythematosus-like dermatitis associated 
      with antihistamine therapy.
PG  - 95-9
AB  - The authors report the occurrence of lichenoid and/or subacute lupus 
      erythematosus-like eruptions in a group of patients receiving agents with 
      antihistaminic properties. In 1 of the patients the eruption clinically resembled 
      lichen planus, while in 5 patients the eruption resembled subacute cutaneous 
      lupus erythematosus (SCLE). At a light microscopic level all cases showed a 
      lichenoid dermatitis and in 4 cases the lesions were interpreted as representing 
      subacute lupus-like eruptions by virtue of the presence of alternating cell poor 
      and lichenoid interface dermatitis, suprabasilar lymphocytosis around 
      degenerating keratinocytes, and dermal mucinosis. Despite the resemblance at a 
      clinical and light microscopic level to SCLE, anti-Ro seropositivity could not be 
      established in any of the cases. One case, however, did demonstrate antihistone 
      antibodies in concert with a high antinuclear antibody titer. A causal 
      association was implicated by virtue of lesional resolution following drug 
      withdrawal. The association of cutaneous eruptions resembling SCLE with 
      antihistamine intake is seemingly a novel one. The possible pathogenetic basis of 
      the eruptions is discussed.
FAU - Crowson, A N
AU  - Crowson AN
AD  - Department of Laboratories, Misericordia General Hospital, Winnipeg, Manitoba, 
      Canada.
FAU - Magro, C M
AU  - Magro CM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Histamine H1 Antagonists)
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Diagnosis, Differential
MH  - Drug Eruptions/*pathology
MH  - Female
MH  - Histamine H1 Antagonists/*adverse effects
MH  - Humans
MH  - Lichenoid Eruptions/*chemically induced/*pathology
MH  - Lupus Erythematosus, Cutaneous/*pathology
MH  - Lymphocytes/pathology
MH  - Male
MH  - Middle Aged
EDAT- 1999/03/19 00:00
MHDA- 1999/03/19 00:01
CRDT- 1999/03/19 00:00
PHST- 1999/03/19 00:00 [pubmed]
PHST- 1999/03/19 00:01 [medline]
PHST- 1999/03/19 00:00 [entrez]
AID - 10.1111/j.1600-0560.1999.tb01809.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 1999 Feb;26(2):95-9. doi: 10.1111/j.1600-0560.1999.tb01809.x.