PMID- 10082485
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 33
IP  - 3
DP  - 1999 Mar
TI  - Parental hyperdynamic circulation predicts insulin resistance in offspring: The 
      Tecumseh Offspring Study.
PG  - 769-74
AB  - Controversy surrounds the pathogenetic mechanisms of the relationship between 
      hyperdynamic circulation and insulin resistance. Two hundred eight children and 
      young adults (mean age, 17.2+/-3.0 years; range, 11 to 26 years) from the 
      Tecumseh Offspring Study whose parents had been assessed with Doppler 
      echocardiography at the age of 34 years during the previous Tecumseh Blood 
      Pressure Study were considered for this analysis. Offspring data were stratified 
      according to tertiles of parental cardiac index. Parents in the top cardiac index 
      tertile had increased heart rate (P=0.001), stroke volume (P=0.0001), left 
      ventricular fractional shortening (P=0.02), and plasma epinephrine (P=0.02) 
      compared with parents in the other tertiles. Body mass index (BMI) and blood 
      pressure were similar in all groups. Offspring of parents with a high cardiac 
      index had greater BMI (P=0.001), skinfold thickness (P=0.008), and waist/hip 
      ratio (P=0.02), higher diastolic blood pressure (P=0.02) and plasma insulin level 
      (P=0.001), and higher heart rate during Stroop's color test (P=0.02) than 
      offspring of parents with a lower cardiac index. In a multivariate regression 
      analysis, offspring BMI was predicted by parental BMI and cardiac index (P=0.0001 
      and 0.003, respectively). The mother-child relationship explained most of the 
      cardiac index-BMI association. In summary, parental hyperdynamic circulation was 
      an important predictor of overweight, abnormal fat distribution, increased blood 
      pressure, and hyperinsulinemia in offspring. Our results illustrate the 
      complexity of interaction between a genetic tendency and its phenotypic 
      expression. We speculate that the degree of beta-adrenergic responsiveness may be 
      a major determinant of the phenotypic differences between the parents and 
      offspring found in this study.
FAU - Palatini, P
AU  - Palatini P
AD  - Dipartimento di Medicina Clinica e Sperimentale, University of Padova, Padova, 
      Italy. palatini@ux1.unipd.it
FAU - Vriz, O
AU  - Vriz O
FAU - Nesbitt, S
AU  - Nesbitt S
FAU - Amerena, J
AU  - Amerena J
FAU - Majahalme, S
AU  - Majahalme S
FAU - Valentini, M
AU  - Valentini M
FAU - Julius, S
AU  - Julius S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Insulin)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Body Mass Index
MH  - Epinephrine/blood
MH  - Female
MH  - Hemodynamics/*genetics
MH  - Humans
MH  - Hypertension/blood/*genetics
MH  - Insulin/blood
MH  - Insulin Resistance/*genetics
MH  - Italy
MH  - Male
MH  - *Nuclear Family
MH  - Sex Factors
MH  - Statistics as Topic
EDAT- 1999/03/19 00:00
MHDA- 1999/03/19 00:01
CRDT- 1999/03/19 00:00
PHST- 1999/03/19 00:00 [pubmed]
PHST- 1999/03/19 00:01 [medline]
PHST- 1999/03/19 00:00 [entrez]
AID - 10.1161/01.hyp.33.3.769 [doi]
PST - ppublish
SO  - Hypertension. 1999 Mar;33(3):769-74. doi: 10.1161/01.hyp.33.3.769.