PMID- 10082504
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 33
IP  - 3
DP  - 1999 Mar
TI  - Prospective analysis of traits related to 6-year change in sodium-lithium 
      countertransport. Gubbio Population Study Research Group.
PG  - 887-93
AB  - Sodium-lithium countertransport (Na-Li CT) activity in red blood cells relates 
      cross-sectionally and longitudinally to blood pressure and hypertension. 
      Lifestyle and metabolic factors relate cross-sectionally to this sodium 
      transporter. The aim of this study was to conduct a prospective analysis of 
      6-year Na-Li CT change and of traits related to Na-Li CT change. In 2183 
      participants in the Gubbio Population Study (972 men and 1211 women; baseline 
      ages, 18 to 74 years), the following data collected at baseline and 6-year 
      follow-up were analyzed: Na-Li CT; gender; age; body mass index (BMI); blood 
      pressure; antihypertensive treatment; alcohol intake; smoking habits; urinary 
      sodium-to-potassium ratio; and plasma cholesterol, glucose, uric acid, sodium, 
      potassium, and triglycerides (measured only at follow-up). Six-year changes were 
      defined as follow-up minus baseline values. Na-Li CT was higher at follow-up than 
      at baseline in both genders (P<0.001). Baseline Na-Li CT; baseline and change 
      values of BMI; and change values of alcohol intake, plasma potassium, and plasma 
      glucose related to Na-Li CT change significantly and independently with control 
      for other variables. Follow-up plasma triglyceride levels also related 
      independently to Na-Li CT change. Coefficients were positive for BMI, alcohol 
      intake, and plasma glucose and triglyceride levels and were negative for baseline 
      Na-Li CT and plasma potassium levels. Baseline and change values of other 
      variables did not relate significantly to Na-Li CT change. In conclusion, in 
      prospective analyses, BMI, alcohol intake, plasma glucose, and lipids were 
      directly related to Na-Li CT change; baseline Na-Li CT and plasma potassium 
      levels were inversely related. The data support the concept that lifestyle and 
      related metabolic factors influence Na-Li CT.
FAU - Cirillo, M
AU  - Cirillo M
AD  - Division of Nephrology, Second Medical School, Naples University, Italy.
FAU - Laurenzi, M
AU  - Laurenzi M
FAU - Panarelli, W
AU  - Panarelli W
FAU - Trevisan, M
AU  - Trevisan M
FAU - Stamler, J
AU  - Stamler J
LA  - eng
GR  - R01HL-40397-02/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Antiporters)
RN  - 0 (Triglycerides)
RN  - 0 (sodium-lithium countertransporter)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 9FN79X2M3F (Lithium)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging/*blood
MH  - Alcohol Drinking
MH  - Antiporters/*blood
MH  - Body Mass Index
MH  - Cholesterol/blood
MH  - Female
MH  - Humans
MH  - Lithium/blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Sodium/blood
MH  - Time Factors
MH  - Triglycerides/blood
EDAT- 1999/03/19 00:00
MHDA- 1999/03/19 00:01
CRDT- 1999/03/19 00:00
PHST- 1999/03/19 00:00 [pubmed]
PHST- 1999/03/19 00:01 [medline]
PHST- 1999/03/19 00:00 [entrez]
AID - 10.1161/01.hyp.33.3.887 [doi]
PST - ppublish
SO  - Hypertension. 1999 Mar;33(3):887-93. doi: 10.1161/01.hyp.33.3.887.