PMID- 10082874
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 819
IP  - 1-2
DP  - 1999 Feb 20
TI  - Blockade of glutamate reuptake in the rat nucleus accumbens increases locomotor 
      activity.
PG  - 165-9
AB  - The effect on locomotor activity of blocking glutamate reuptake in the nucleus 
      accumbens (NAcc) was investigated in the rat. Bilateral intracranial 
      microinjections into the NAcc of the selective glutamate reuptake blocker, 
      l-trans-pyrrolidine-2,4-dicarboxylic acid (PDC), were made in the freely moving 
      rat and locomotor activity subsequently measured for 2 h. Different groups of 
      rats injected with one of three doses of PDC (0.5, 5 or 10 nmole/0.5 microl/side) 
      showed significant dose-dependent increases in both horizontal and vertical 
      locomotor activity relative to control rats that received injections of the 
      saline vehicle. These findings indicate that glutamate in the NAcc plays an 
      important role in the production of locomotor behaviors.
CI  - Copyright 1999 Elsevier Science B. V.
FAU - Kim, J H
AU  - Kim JH
AD  - Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue, 
      MC 3077, Chicago, IL 60637, USA.
FAU - Vezina, P
AU  - Vezina P
LA  - eng
GR  - DA-09860/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Dicarboxylic Acids)
RN  - 0 (Neurotransmitter Uptake Inhibitors)
RN  - 0 (Pyrrolidines)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 99319-03-6 (pyrrolidine-2,4-dicarboxylic acid)
SB  - IM
MH  - Animals
MH  - Dicarboxylic Acids/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Glutamic Acid/*metabolism
MH  - Male
MH  - Microinjections
MH  - Motor Activity/drug effects/*physiology
MH  - Neurotransmitter Uptake Inhibitors/*pharmacology
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Pyrrolidines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 1999/03/20 00:00
MHDA- 1999/03/20 00:01
CRDT- 1999/03/20 00:00
PHST- 1999/03/20 00:00 [pubmed]
PHST- 1999/03/20 00:01 [medline]
PHST- 1999/03/20 00:00 [entrez]
AID - S0006-8993(98)01353-5 [pii]
AID - 10.1016/s0006-8993(98)01353-5 [doi]
PST - ppublish
SO  - Brain Res. 1999 Feb 20;819(1-2):165-9. doi: 10.1016/s0006-8993(98)01353-5.