PMID- 10084281
OWN - NLM
STAT- MEDLINE
DCOM- 19990609
LR  - 20191103
IS  - 0098-6577 (Print)
IS  - 0098-6577 (Linking)
VI  - 69
DP  - 1999 Mar
TI  - Iron and anemia of chronic disease.
PG  - S12-7
AB  - Anemia of chronic disease (ACD) is the most frequent anemia found in hospitalized 
      patients, often occurring in subjects suffering from chronic inflammatory 
      disorders. The underlying diversion of iron traffic leads to a withdrawal of the 
      metal from the sites of erythropoiesis and the circulation to the storage 
      compartment in the reticuloendothelial system, thus resulting, at the same time, 
      in hypoferremia and hyperferritinemia. Proinflammatory and antiinflammatory 
      cytokines, acute-phase proteins, and radicals are prominently involved in causing 
      these disturbances of iron homeostasis. The role of these factors, as well as the 
      pathophysiological reasons for the development of ACD, is discussed in this 
      review.
FAU - Weiss, G
AU  - Weiss G
AD  - Department of Internal Medicine, University Hospital, Innsbruck, Austria. 
      guenter.weiss@uibk.ac.at
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Kidney Int Suppl
JT  - Kidney international. Supplement
JID - 7508622
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Free Radicals)
RN  - 0 (Hormones)
RN  - 0 (Receptors, Transferrin)
RN  - 0 (Recombinant Proteins)
RN  - 11096-26-7 (Erythropoietin)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Acute-Phase Proteins/metabolism
MH  - Anemia/drug therapy/*etiology/*metabolism
MH  - Chronic Disease
MH  - Erythropoietin/therapeutic use
MH  - Free Radicals/metabolism
MH  - Hormones/metabolism
MH  - Humans
MH  - Iron/*metabolism
MH  - Receptors, Transferrin/metabolism
MH  - Recombinant Proteins
MH  - Th1 Cells/metabolism
MH  - Th2 Cells/metabolism
RF  - 72
EDAT- 1999/03/20 00:00
MHDA- 1999/03/20 00:01
CRDT- 1999/03/20 00:00
PHST- 1999/03/20 00:00 [pubmed]
PHST- 1999/03/20 00:01 [medline]
PHST- 1999/03/20 00:00 [entrez]
AID - S0085-2538(15)46231-3 [pii]
AID - 10.1046/j.1523-1755.1999.055suppl.69012.x [doi]
PST - ppublish
SO  - Kidney Int Suppl. 1999 Mar;69:S12-7. doi: 
      10.1046/j.1523-1755.1999.055suppl.69012.x.