PMID- 10085462
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20171101
IS  - 1422-4933 (Print)
IS  - 1422-4933 (Linking)
VI  - 8
IP  - 1-2
DP  - 1999 Jan-Apr
TI  - New actions of melatonin on tumor metabolism and growth.
PG  - 49-55
AB  - Melatonin is an important inhibitor of cancer growth promotion while the 
      essential polyunsaturated fatty acid, linoleic acid is an important promoter of 
      cancer progression. Following its rapid uptake by tumor tissue, linoleic acid is 
      oxidized via a lipoxygenase to the growth-signaling molecule, 
      13-hydroxyoctadecadienoic acid (13-HODE) which stimulates epidermal growth factor 
      (EGF)-dependent mitogenesis. The uptake of plasma linoleic acid and its 
      metabolism to 13-HODE by rat hepatoma 7288CTC, which expresses both fatty acid 
      transport protein and melatonin receptors, is inhibited by melatonin in a 
      circadian-dependent manner. This inhibitory effect of melatonin is reversible 
      with either pertussis toxin, forskolin or cAMP. While melatonin inhibits tumor 
      linoleic acid uptake, metabolism and growth, pinealectomy or constant light 
      exposure stimulates these processes. Thus, melatonin and linoleic acid represent 
      two important environmental signals that interact in a unique manner to regulate 
      tumor progression and ultimately the host-cancer balance.
FAU - Blask, D E
AU  - Blask DE
AD  - Bassett Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY 
      13326-1394, USA. dblask@usa.net
FAU - Sauer, L A
AU  - Sauer LA
FAU - Dauchy, R
AU  - Dauchy R
FAU - Holowachuk, E W
AU  - Holowachuk EW
FAU - Ruhoff, M S
AU  - Ruhoff MS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Biol Signals Recept
JT  - Biological signals and receptors
JID - 9808792
RN  - 9KJL21T0QJ (Linoleic Acid)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Cell Division/drug effects/radiation effects
MH  - Humans
MH  - Light
MH  - Linoleic Acid/metabolism/pharmacokinetics
MH  - Liver Neoplasms, Experimental/*drug therapy/metabolism/pathology
MH  - Male
MH  - Melatonin/*pharmacology/physiology
MH  - Pineal Gland/physiopathology
MH  - Rats
MH  - Rats, Inbred BUF
MH  - Signal Transduction
RF  - 20
EDAT- 1999/03/23 03:02
MHDA- 2000/08/16 11:00
CRDT- 1999/03/23 03:02
PHST- 1999/03/23 03:02 [pubmed]
PHST- 2000/08/16 11:00 [medline]
PHST- 1999/03/23 03:02 [entrez]
AID - 14568 [pii]
AID - 10.1159/000014568 [doi]
PST - ppublish
SO  - Biol Signals Recept. 1999 Jan-Apr;8(1-2):49-55. doi: 10.1159/000014568.