PMID- 10087093
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20191023
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 7
DP  - 1999 Apr 1
TI  - Central neuronal circuit innervating the lordosis-producing muscles defined by 
      transneuronal transport of pseudorabies virus.
PG  - 2823-33
AB  - The lordosis reflex is a hormone-dependent behavior displayed by female rats 
      during mating. This study used the transneuronal tracer pseudorabies virus (PRV) 
      to investigate the CNS network that controls the lumbar epaxial muscles that 
      produce this posture. After PRV was injected into lumbar epaxial muscles, the 
      time course analysis of CNS viral infection showed progressively more PRV-labeled 
      neurons in higher brain structures after longer survival times. In particular, 
      the medullary reticular formation, periaqueductal gray (PAG), and ventromedial 
      nucleus of the hypothalamus (VMN) were sequentially labeled with PRV, which 
      supports the proposed hierarchical network of lordosis control. Closer inspection 
      of the PRV-immunoreactive neurons in the PAG revealed a marked preponderance of 
      spheroid neurons, rather than fusiform or triangular morphologies. Furthermore, 
      PRV-immunoreactive neurons were concentrated in the ventrolateral column, rather 
      than the dorsal, dorsolateral, or lateral columns of the PAG. Localization of the 
      PRV-labeled neurons in the VMN indicated that the majority were located in the 
      ventrolateral subdivision, although some were also in other subdivisions of the 
      VMN. As expected, labeled cells also were found in areas traditionally associated 
      with sympathetic outflow to blood vessels and motor pathways, including the 
      intermediolateral nucleus of the spinal cord, the paraventricular hypothalamic 
      nucleus, the red nucleus, and the motor cortex. These results suggest that the 
      various brain regions along the neuraxis previously implicated in the lordosis 
      reflex are indeed serially connected.
FAU - Daniels, D
AU  - Daniels D
AD  - Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 
      19104-6196, USA.
FAU - Miselis, R R
AU  - Miselis RR
FAU - Flanagan-Cato, L M
AU  - Flanagan-Cato LM
LA  - eng
GR  - GM27739/GM/NIGMS NIH HHS/United States
GR  - MH54712/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Animals
MH  - Biological Transport/physiology
MH  - Female
MH  - Herpesvirus 1, Suid/*physiology
MH  - Immunohistochemistry
MH  - Male
MH  - Medulla Oblongata/physiology
MH  - Mesencephalon/physiology
MH  - Muscle, Skeletal/*physiology
MH  - Neural Pathways/physiology
MH  - Neurons/*physiology
MH  - Pons/physiology
MH  - Posture/*physiology
MH  - Prosencephalon/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sexual Behavior, Animal/*physiology
MH  - Spinal Cord/physiology
PMC - PMC6786090
EDAT- 1999/03/23 00:00
MHDA- 1999/03/23 00:01
PMCR- 1999/10/01
CRDT- 1999/03/23 00:00
PHST- 1999/03/23 00:00 [pubmed]
PHST- 1999/03/23 00:01 [medline]
PHST- 1999/03/23 00:00 [entrez]
PHST- 1999/10/01 00:00 [pmc-release]
AID - 2907 [pii]
AID - 10.1523/JNEUROSCI.19-07-02823.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Apr 1;19(7):2823-33. doi: 10.1523/JNEUROSCI.19-07-02823.1999.