PMID- 10087948
OWN - NLM
STAT- MEDLINE
DCOM- 19990407
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 109
IP  - 2
DP  - 1999 Mar
TI  - Premature centromere division in patients with multiple endocrine neoplasia type 
      1.
PG  - 138-40
AB  - Frequency of mitoses with premature centromere division (PCD) was examined in 
      lymphocytes from subjects with multiple endocrine neoplasia type 1 (MEN 1). An 
      increase in PCD after exposure to an alkylating agent was observed in subjects 
      with MEN 1 who carry a heterozygous MEN1 gene mutation but not in normal controls 
      or in affected subjects without the MEN1 gene mutation. These findings support 
      the inclusion of MEN 1 as a chromosome instability syndrome and recognition of 
      PCD as a manifestation of chromosome instability. Furthermore, these results 
      suggest that the MEN1 gene product may function to maintain the integrity of DNA.
FAU - Sakurai, A
AU  - Sakurai A
AD  - Department of Geriatrics, Endocrinology, and Metabolism, Shinshu University 
      School of Medicine, Matsumoto, Japan.
FAU - Katai, M
AU  - Katai M
FAU - Itakura, Y
AU  - Itakura Y
FAU - Ikeo, Y
AU  - Ikeo Y
FAU - Hashizume, K
AU  - Hashizume K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Epoxy Compounds)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 60OB65YNAB (diepoxybutane)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Centromere/*genetics
MH  - Epoxy Compounds/pharmacology
MH  - Heterozygote
MH  - Humans
MH  - Lymphocytes/drug effects
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Mutation
MH  - Neoplasm Proteins/genetics
MH  - *Proto-Oncogene Proteins
MH  - Reference Values
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
AID - S0165460898001563 [pii]
AID - 10.1016/s0165-4608(98)00156-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Mar;109(2):138-40. doi: 
      10.1016/s0165-4608(98)00156-3.