PMID- 10088610
OWN - NLM
STAT- MEDLINE
DCOM- 19990325
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 65
IP  - 2
DP  - 1999 Feb
TI  - LPS down-regulates the expression of chemokine receptor CCR2 in mice and 
      abolishes macrophage infiltration in acute inflammation.
PG  - 265-9
AB  - Interactions between chemokines and their specific receptors are important for 
      leukocyte trafficking. The CC-chemokine monocyte chemoattractant protein-1 
      (MCP-1) and its specific receptor CCR2 are essential in monocytic infiltration 
      and have been associated with several inflammatory diseases. It has been reported 
      that several endotoxin and proinflammatory cytokines inhibit CCR2 expression in 
      vitro in human monocytes. We report here that lipopolysaccharides (LPS) 
      down-regulated CCR2 expression both in vitro and in vivo. Injection of LPS into 
      mice dramatically reduced the expression of CCR2 on the surface of peripheral 
      blood cells and completely blocked macrophage infiltration into the peritoneal 
      cavity in response to thioglycollate elicitation. In addition, treatment of mice 
      with LPS reduced their efficiency to clear Listeria monocytogenes infection. 
      These results suggest that down-regulation of CCR2 and blockage of monocyte 
      infiltration may contribute to the inhibition of macrophage function in vivo by a 
      low dose of LPS.
FAU - Zhou, Y
AU  - Zhou Y
AD  - Department of Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, 
      Princeton, NJ 08543-4000, USA.
FAU - Yang, Y
AU  - Yang Y
FAU - Warr, G
AU  - Warr G
FAU - Bravo, R
AU  - Bravo R
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (CCR2 protein, human)
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Thioglycolates)
SB  - IM
MH  - Animals
MH  - Down-Regulation
MH  - Immunity, Cellular
MH  - Lipopolysaccharides/*pharmacology
MH  - Listeria monocytogenes
MH  - Listeriosis/*immunology
MH  - Macrophage Activation/*drug effects
MH  - Mice
MH  - Peritoneal Cavity/cytology
MH  - Peritonitis/chemically induced/immunology/*microbiology
MH  - Receptors, CCR2
MH  - *Receptors, Chemokine
MH  - Receptors, Cytokine/*drug effects/metabolism
MH  - Thioglycolates
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
AID - 10.1002/jlb.65.2.265 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1999 Feb;65(2):265-9. doi: 10.1002/jlb.65.2.265.