PMID- 10089060
OWN - NLM
STAT- MEDLINE
DCOM- 19990527
LR  - 20151119
IS  - 0392-9078 (Print)
IS  - 0392-9078 (Linking)
VI  - 17
IP  - 4
DP  - 1998 Dec
TI  - Serum concentrations of proinflammatory cytokines in advanced non small cell lung 
      cancer patients.
PG  - 413-7
AB  - To assess the relationship between serum concentrations of proinflammatory 
      cytokines and prognosis of non small cell lung cancer (NSCLC), we evaluated the 
      serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta 
      (IL-1-beta) and interleukin-6 (IL-6) in 60 patients with untreated advanced 
      NSCLC. Mean cytokines concentrations in patients were significantly higher than 
      in the control population. Patients with metastatic disease had higher levels 
      than those with undisseminated disease. Finally, in patients with tumor 
      progression we observed an increase of cytokines serum levels. These results 
      suggest that in NSCLC elevated serum levels of proinflammatory cytokines may have 
      prognostic value being associated with a worse prognosis.
FAU - De Vita, F
AU  - De Vita F
AD  - Cattedra di Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale 
      F. Magrassi, II Universita di Napoli, Naples, Italy.
FAU - Orditura, M
AU  - Orditura M
FAU - Auriemma, A
AU  - Auriemma A
FAU - Infusino, S
AU  - Infusino S
FAU - Catalano, G
AU  - Catalano G
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Exp Clin Cancer Res
JT  - Journal of experimental & clinical cancer research : CR
JID - 8308647
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*blood
MH  - Carcinoma, Non-Small-Cell Lung/*blood/diagnosis/pathology
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*blood/diagnosis/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
PST - ppublish
SO  - J Exp Clin Cancer Res. 1998 Dec;17(4):413-7.