PMID- 10089231
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20190831
IS  - 0171-967X (Print)
IS  - 0171-967X (Linking)
VI  - 64
IP  - 4
DP  - 1999 Apr
TI  - Effect of anterior cruciate ligament injury of the knee on bone mineral density 
      of the spine and affected lower extremity: a prospective one-year follow-Up 
      study.
PG  - 357-63
AB  - The objective of this 1-year prospective follow-up study was to assess, with 
      dual-energy X-ray absorptiometry (DXA), the effect of an anterior cruciate 
      ligament (ACL) injury of the knee on areal bone mineral density (BMD) of the 
      injured extremity and lumbar spine in two separate patient groups: 21 surgically 
      treated patients (group A) and 12 conservatively treated patients (group B). 
      Clinical and functional status of the patients and BMD of the spine (L2-L4), 
      dominant distal radius, femoral neck, trochanter area of the femur, distal femur, 
      patella, proximal tibia, and calcaneus of both lower extremities were determined 
      at the time of the injury and after 4, 8, and 12 months. A surgically treated, 
      complete ACL rupture (group A) resulted in considerable and statistically 
      significant bone loss to the affected knee (distal femur 21%, patella 17%, 
      proximal tibia 14%; P < 0.001 in each), whereas the other sites were clearly less 
      affected. Patients with a conservatively treated, complete or partial ACL injury 
      (group B) had only a small but statistically significant bone loss at the patella 
      (-3%; P = 0.005) and proximal tibia (-2%; P = 0.022) of the injured knee, and the 
      other sites remained unchanged. The obvious differences between the groups A and 
      B in the severity of the injury itself (complete or partial tear), its treatment 
      (surgical or conservative), and subsequent rehabilitation (longer 
      nonweight-bearing times in group A) explain these different BMD results, and the 
      forthcoming years will show whether the considerable posttraumatic osteoporosis 
      in the affected knee of group A patients will finally recover, and if so, to what 
      extent.
FAU - Leppala, J
AU  - Leppala J
AD  - Accident and Trauma Research Center, UKK Institute for Health Promotion Research, 
      Tampere, Finland.
FAU - Kannus, P
AU  - Kannus P
FAU - Natri, A
AU  - Natri A
FAU - Pasanen, M
AU  - Pasanen M
FAU - Sievanen, H
AU  - Sievanen H
FAU - Vuori, I
AU  - Vuori I
FAU - Jarvinen, M
AU  - Jarvinen M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Calcif Tissue Int
JT  - Calcified tissue international
JID - 7905481
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adolescent
MH  - Adult
MH  - Anterior Cruciate Ligament/physiopathology
MH  - *Anterior Cruciate Ligament Injuries
MH  - *Bone Density
MH  - Bone Resorption/etiology/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Knee Joint
MH  - Leg/*physiopathology
MH  - Lumbar Vertebrae/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radius/physiopathology
MH  - Rupture/physiopathology
EDAT- 1999/03/25 00:00
MHDA- 1999/03/25 00:01
CRDT- 1999/03/25 00:00
PHST- 1999/03/25 00:00 [pubmed]
PHST- 1999/03/25 00:01 [medline]
PHST- 1999/03/25 00:00 [entrez]
AID - 10.1007/s002239900632 [doi]
PST - ppublish
SO  - Calcif Tissue Int. 1999 Apr;64(4):357-63. doi: 10.1007/s002239900632.