PMID- 10089936
OWN - NLM
STAT- MEDLINE
DCOM- 19990407
LR  - 20190826
IS  - 0021-4868 (Print)
IS  - 0021-4868 (Linking)
VI  - 39
IP  - 6
DP  - 1998 Nov
TI  - Long-term effects of the angiotensin-converting enzyme inhibitor enalapril on 
      chronic heart failure. Examination by 123I-MIBG imaging.
PG  - 743-51
AB  - To examine the long-term effects of the angiotensin-converting enzyme (ACE) 
      inhibitor enalapril on chronic heart failure, 10 patients (7 men and 3 women, 
      mean age: 62 +/- 11 years) with chronic stable heart failure, classified as New 
      York Heart Association (NYHA) functional class 2-3 for more than 3 months, and a 
      left ventricular ejection fraction less than 45% were treated with 2.5-5.0 mg of 
      enalapril once a day for 3-15 months (mean 7 months). The causes of heart failure 
      were old myocardial infarction (n = 7), hypertension (n = 2), and atrial 
      fibrillation (n = 1). Radioiodinated metaiodobenzyl guanidine (123I-MIBG) 
      imaging, radionuclide angiography, and treadmill exercise test were performed 
      before and after the treatment. With enalapril treatment, (1) left ventricular 
      ejection fraction (LVEF) increased significantly from 38.3 +/- 6.9% to 47.5 +/- 
      14.7%; (2) sub-maximal exercise time increased significantly from 205 +/- 112 to 
      272 +/- 120 seconds; (3) the heart to mediastinum (H/M) ratio of 123I-MIBG 
      increased significantly (early image: 1.99 +/- 0.38 versus 2.20 +/- 0.50; delayed 
      image: 1.86 +/- 0.44 versus 2.09 +/- 0.51); and (4) the washout rate of 123I-MIBG 
      decreased slightly from 29.1 +/- 9.1% to 25.4 +/- 7.0%. The improvement rate of 
      LVEF was significantly correlated with the improvement rates of the H/M ratio and 
      washout rate after treatment with enalapril. Thus, the long-term effects of 
      enalapril can be observed in the cardiac sympathetic nervous system, and 
      123I-MIBG imaging appears to be useful for evaluating the therapeutic effects of 
      enalapril on the cardiac sympathetic nervous system in patients with chronic 
      heart failure.
FAU - Soeki, T
AU  - Soeki T
AD  - Department of Cardiology, Zentsuji National Hospital, Kagawa, Japan.
FAU - Tamura, Y
AU  - Tamura Y
FAU - Bandou, K
AU  - Bandou K
FAU - Tanaka, H
AU  - Tanaka H
FAU - Takeichi, N
AU  - Takeichi N
FAU - Shinohara, H
AU  - Shinohara H
FAU - Yui, Y
AU  - Yui Y
FAU - Fukuda, N
AU  - Fukuda N
FAU - Sui, O
AU  - Sui O
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Japan
TA  - Jpn Heart J
JT  - Japanese heart journal
JID - 0401175
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
RN  - 69PN84IO1A (Enalapril)
SB  - IM
MH  - *3-Iodobenzylguanidine
MH  - Aged
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/*therapeutic use
MH  - Antihypertensive Agents/administration & dosage/*therapeutic use
MH  - Atrial Fibrillation/complications
MH  - Chronic Disease
MH  - Enalapril/administration & dosage/*therapeutic use
MH  - Female
MH  - Heart Failure/diagnostic imaging/*drug therapy/physiopathology
MH  - Humans
MH  - Hypertension/complications
MH  - Iodine Radioisotopes
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications
MH  - Radionuclide Imaging
MH  - *Radiopharmaceuticals
MH  - Stroke Volume
MH  - Ventricular Function, Left
EDAT- 1999/03/25 00:00
MHDA- 1999/03/25 00:01
CRDT- 1999/03/25 00:00
PHST- 1999/03/25 00:00 [pubmed]
PHST- 1999/03/25 00:01 [medline]
PHST- 1999/03/25 00:00 [entrez]
AID - 10.1536/ihj.39.743 [doi]
PST - ppublish
SO  - Jpn Heart J. 1998 Nov;39(6):743-51. doi: 10.1536/ihj.39.743.