PMID- 10090122
OWN - NLM
STAT- MEDLINE
DCOM- 19990526
LR  - 20220408
IS  - 0733-2467 (Print)
IS  - 0733-2467 (Linking)
VI  - 18
IP  - 1
DP  - 1999
TI  - Interrelationships of bladder compliance with age, detrusor instability, and 
      obstruction in elderly men with lower urinary tract symptoms.
PG  - 3-15
AB  - Data on the interrelationships of bladder compliance (BC), detrusor instability 
      (DI), and bladder outflow obstruction (BOO) in elderly men with lower urinary 
      tract symptoms (LUTS) are scarce and were therefore assessed in this study. 
      Principle inclusion criteria for this study were men aged > or = 50 years 
      suffering from LUTS as defined by an International Prostate Symptoms Score (IPSS) 
      of > or = 7 and a peak flow rate (Qmax) of < or = 15 ml/sec. Patients with 
      previous surgery of the bladder, prostate, or urethra as well as a pathological 
      neurourological status were excluded from this study. The following parameters 
      were studied in all patients: IPSS, prostate volume calculated by transrectal 
      ultrasonography, free uroflow study, post-void residual volume determined by 
      transurethral catheterization, and a multichannel pressure flow study (pQS). A 
      group of 170 men were included in the analysis. The mean BC in the overall group 
      was 32 +/- 2 ml/cm H2O (mean +/- standard error of the mean [SEM]; range, 4-100 
      ml/cm H2O). In 36.5% of patients, BC was significantly reduced (< or = 20 ml/cm 
      H2O), and in a further 37.1%, it ranged from 20 to 40 ml/cm H2O. BC decreased 
      statistically significantly (p < 0.05) in patients with advanced age, lower Qmax, 
      higher voiding pressures, and larger prostates. In men with DI (n = 61), mean BC 
      was significantly lower (22 +/- 3 ml/cm H2O) compared to those without (37 +/- 3 
      ml/cm H2O; p = 0.001; n = 109). Patients with severe BOO as defined by a linear 
      passive urethral resistance relationship of > or = 3 (n = 109), had a 
      significantly lower BC (23 +/- 2 ml/cm H2O) compared to those without or minimal 
      obstruction only (39 +/- 3 ml/cm H2O; p = 0.0002; n = 61). Stepwise logistic 
      regression analysis revealed that DI, a low bladder capacity, and a high maximum 
      detrusor pressure were independent predictors of markedly reduced BC (< 20 ml/cm 
      H2O). BC is decreased in elderly men with high voiding pressures, BOO, and DI. 
      The mechanism leading to the reduction of BC under these circumstances is largely 
      unknown and could result from cytostructural alterations of the detrusor and 
      changes in detrusor innervation.
FAU - Madersbacher, S
AU  - Madersbacher S
AD  - Department of Urology, University of Vienna, Austria. madersbacher@hotmail.com
FAU - Pycha, A
AU  - Pycha A
FAU - Klingler, C H
AU  - Klingler CH
FAU - Mian, C
AU  - Mian C
FAU - Djavan, B
AU  - Djavan B
FAU - Stulnig, T
AU  - Stulnig T
FAU - Marberger, M
AU  - Marberger M
LA  - eng
PT  - Comment
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Neurourol Urodyn
JT  - Neurourology and urodynamics
JID - 8303326
SB  - IM
CON - Neurourol Urodyn. 1999;18(1):1-2. PMID: 10090121
MH  - Aged
MH  - Aging/*physiology
MH  - Compliance
MH  - Endosonography
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Contraction
MH  - Pressure
MH  - Prognosis
MH  - Prostatic Hyperplasia/complications/diagnostic imaging/physiopathology
MH  - Rectum/diagnostic imaging
MH  - Urinary Bladder/*physiopathology
MH  - Urinary Bladder Neck Obstruction/diagnostic imaging/etiology/*physiopathology
MH  - Urodynamics
EDAT- 1999/03/25 03:02
MHDA- 2000/06/20 09:00
CRDT- 1999/03/25 03:02
PHST- 1999/03/25 03:02 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/03/25 03:02 [entrez]
AID - 10.1002/(SICI)1520-6777(1999)18:1<3::AID-NAU2>3.0.CO;2-4 [pii]
AID - 10.1002/(sici)1520-6777(1999)18:1<3::aid-nau2>3.0.co;2-4 [doi]
PST - ppublish
SO  - Neurourol Urodyn. 1999;18(1):3-15. doi: 
      10.1002/(sici)1520-6777(1999)18:1<3::aid-nau2>3.0.co;2-4.