PMID- 10090164
OWN - NLM
STAT- MEDLINE
DCOM- 19990507
LR  - 20131121
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 26
IP  - 3
DP  - 1999 Mar
TI  - Circulating levels of beta-chemokines in systemic lupus erythematosus.
PG  - 568-73
AB  - OBJECTIVE: Recent evidence suggests the role of beta-chemokines and their 
      receptors in human immunodeficiency virus infection. We examined the serum levels 
      of beta-chemokines in patients with systemic lupus erythematosus (SLE). METHODS: 
      The serum levels of beta-chemokines, macrophage inflammatory protein-1alpha 
      (MIP-1alpha), MIP-1beta, RANTES, and monocyte chemoattractant protein-1 (MCP-1) 
      in patients with SLE were determined by ELISA. RESULTS: There were significant 
      differences between the patients with SLE and healthy controls in the serum 
      concentrations of RANTES (p < 0.001) and MCP-1 (p < 0.01), but not MIP-1alpha (p 
      = 0.07) and MIP-1beta (p = 0.68). A decrease of RANTES and an increase of MCP-1 
      was observed with the progression of disease activity in the patients with SLE. 
      CONCLUSION: Changes in the serum levels of RANTES and MCP-1 may indicate an 
      interaction between SLE disease activity and the production of beta-chemokines.
FAU - Kaneko, H
AU  - Kaneko H
AD  - Department of Rheumatology and Internal Medicine, Juntendo University School of 
      Medicine, Tokyo, Japan.
FAU - Ogasawara, H
AU  - Ogasawara H
FAU - Naito, T
AU  - Naito T
FAU - Akimoto, H
AU  - Akimoto H
FAU - Lee, S
AU  - Lee S
FAU - Hishikawa, T
AU  - Hishikawa T
FAU - Sekigawa, I
AU  - Sekigawa I
FAU - Tokano, Y
AU  - Tokano Y
FAU - Takasaki, Y
AU  - Takasaki Y
FAU - Hirose, S I
AU  - Hirose SI
FAU - Hashimoto, H
AU  - Hashimoto H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Autoantibodies)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 9007-49-2 (DNA)
RN  - 9842X06Q6M (Betamethasone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoantibodies/blood
MH  - Betamethasone/therapeutic use
MH  - Chemokine CCL2/*blood
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/*blood
MH  - DNA/immunology
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*blood/drug therapy/pathology
MH  - Macrophage Inflammatory Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Radioimmunoassay
EDAT- 1999/03/25 00:00
MHDA- 1999/03/25 00:01
CRDT- 1999/03/25 00:00
PHST- 1999/03/25 00:00 [pubmed]
PHST- 1999/03/25 00:01 [medline]
PHST- 1999/03/25 00:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 1999 Mar;26(3):568-73.