PMID- 10090539
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20061115
IS  - 0803-5253 (Print)
IS  - 0803-5253 (Linking)
VI  - 88
IP  - 1
DP  - 1999 Jan
TI  - Effects of maternal dietary avoidance during lactation on allergy in children at 
      10 years of age.
PG  - 7-12
AB  - This study investigated the long-term effects of maternal dietary avoidance 
      during lactation on the occurrence of atopic symptoms, development of 
      immunoglobulin E (IgE) antibodies to food and inhaled allergens and occurrence of 
      positive skin-prick tests (SPT) in 65 children with a family history of atopy 
      whose mothers adhered to a diet devoid of eggs, cow's milk and fish during the 
      first 3 months of lactation (D group) and in a matched group of 50 children with 
      mothers not practising such a diet (ND group). The diets of the D and ND children 
      were similar. All children attended 7 follow-ups from the age of 3 months to the 
      age of 10 y. After the first follow-up there was a 100% retention of 
      participants. The results of the seventh follow-up at 10 y are presented. Total 
      IgE values and IgE antibodies to seven food and seven inhaled allergens were 
      determined by the Phadebas IgE CAP and the Phadebas RAST, respectively. SPT were 
      conducted for five food and seven inhaled allergens. High rates of atopic 
      symptoms occurred in both groups, but there were no differences between the 
      groups. Sensitization to the three foods avoided by the mothers during lactation 
      was similar, but the overall test reactivity to foods was lower in the D group. 
      Sensitization to inhaled allergens was similar in the two groups. During the 10 y 
      of follow-up, there was no difference between the groups in the occurrence of 
      indoor furred animals, tobacco smoking, changes in heredity for atopy or 
      development of total IgE, but a higher rate of maternal sensitization was found 
      in the ND group, as judged by a screening test for IgE antibodies to inhalants 
      (Phadiatop). The results do not support general recommendations to implement 
      prophylactic maternal dietary avoidance during lactation in allergy-prone 
      families.
FAU - Hattevig, G
AU  - Hattevig G
AD  - Department of Paediatrics, Central Hospitals in Skovde, Sweden.
FAU - Sigurs, N
AU  - Sigurs N
FAU - Kjellman, B
AU  - Kjellman B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Breast Feeding
MH  - Child
MH  - *Diet
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*prevention & control
MH  - Immunoglobulin E/analysis
MH  - Radioallergosorbent Test
MH  - Smoking
EDAT- 1999/03/25 00:00
MHDA- 1999/03/25 00:01
CRDT- 1999/03/25 00:00
PHST- 1999/03/25 00:00 [pubmed]
PHST- 1999/03/25 00:01 [medline]
PHST- 1999/03/25 00:00 [entrez]
PST - ppublish
SO  - Acta Paediatr. 1999 Jan;88(1):7-12.