PMID- 10090630
OWN - NLM
STAT- MEDLINE
DCOM- 19990511
LR  - 20190831
IS  - 0301-5548 (Print)
IS  - 0301-5548 (Linking)
VI  - 79
IP  - 4
DP  - 1999 Mar
TI  - Effect of acute and chronic exercise on plasma amino acids and prolactin 
      concentrations and on [3H]ketanserin binding to serotonin2A receptors on human 
      platelets.
PG  - 318-24
AB  - The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been shown to 
      modulate various physiological and psychological functions such as fatigue. 
      Altered regulation of the serotonergic system has been suggested to play a role 
      in response to exercise stress. In the present study, the influence was 
      investigated of acute endurance exercise and short-term increase in the amount of 
      training on the concentrations of the 5-HT precursor tryptophan (TRP), of 
      prolactin (PRL) and of branched-chain amino acids (BCAA) in the blood, as well as 
      on the binding of [3H]ketanserin to the serotonin-2A (5-HT2A) receptors on 
      platelets. Nine healthy endurance-trained men were tested the day before (I) and 
      after (II) a 9-day training programme. Samples of venous blood were drawn after 
      an overnight fast and following 5 h of cycling. Fasted and post-exercise plasma 
      concentrations of free TRP, BCAA and free TRP:BCAA ratio did not differ between I 
      and II. A significant decrease of plasma BCAA (P < 0.01) and significant 
      augmentations of plasma free TRP, free TRP:BCAA ratio and PRL (P < 0.01) were 
      found post-exercise. The increase in plasma PRL was smaller in II compared with 
      I. Acute endurance exercise reduced the density of platelet 5-HT2A receptor 
      [3H]ketanserin binding sites at I and II (P < 0.05). The basal density of the 
      binding sites and the affinity of [3H]ketanserin for these binding sites were 
      unaffected by an increase in the amount of training. The present results support 
      the hypothesis that acute endurance exercise may increase 5-HT availability. This 
      was reflected in the periphery by increased concentration of the 5-HT precursor 
      free TRP, by increased plasma PRL concentration, and by a reduction of 5-HT2A 
      receptors on platelets. It remains to be resolved whether these alterations in 
      the periphery occur in parallel with an increase in the availability of 5-HT in 
      the brain.
FAU - Struder, H K
AU  - Struder HK
AD  - Institute of Sports Games, German Sport University, Cologne.
FAU - Hollmann, W
AU  - Hollmann W
FAU - Platen, P
AU  - Platen P
FAU - Wostmann, R
AU  - Wostmann R
FAU - Weicker, H
AU  - Weicker H
FAU - Molderings, G J
AU  - Molderings GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Appl Physiol Occup Physiol
JT  - European journal of applied physiology and occupational physiology
JID - 0410266
RN  - 0 (Amino Acids)
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Receptors, Serotonin)
RN  - 10028-17-8 (Tritium)
RN  - 8DUH1N11BX (Tryptophan)
RN  - 9002-62-4 (Prolactin)
RN  - 97F9DE4CT4 (Ketanserin)
SB  - IM
MH  - Adult
MH  - Amino Acids/*blood
MH  - Amino Acids, Branched-Chain/blood
MH  - Blood Platelets/*metabolism
MH  - Exercise/*physiology
MH  - Humans
MH  - Ketanserin/*blood
MH  - Male
MH  - Osmolar Concentration
MH  - Physical Endurance/physiology
MH  - Prolactin/*blood
MH  - Receptors, Serotonin/*blood
MH  - Time Factors
MH  - Tritium
MH  - Tryptophan/blood
EDAT- 1999/03/25 00:00
MHDA- 1999/03/25 00:01
CRDT- 1999/03/25 00:00
PHST- 1999/03/25 00:00 [pubmed]
PHST- 1999/03/25 00:01 [medline]
PHST- 1999/03/25 00:00 [entrez]
AID - 10.1007/s004210050514 [doi]
PST - ppublish
SO  - Eur J Appl Physiol Occup Physiol. 1999 Mar;79(4):318-24. doi: 
      10.1007/s004210050514.