PMID- 10091712 OWN - NLM STAT- MEDLINE DCOM- 19990622 LR - 20181201 IS - 1230-6002 (Print) IS - 1230-6002 (Linking) VI - 50 IP - 4-5 DP - 1998 Jul-Oct TI - Behavioral studies of the effects of moderate oligemic hypoxia caused by bilateral clamping of carotid arteries in mice. Impairment of spatial working memory. PG - 279-89 AB - The experiments carried out on Albino Swiss mice indicated that bilateral clamping of carotid arteries (BCCA) for 30 min caused no neuronal damage but produced an increase in GABA content in the hippocampus, striatum and frontal cortex. The behavioral studies have shown that BCCA did not influence the motor coordination, the spontaneous locomotor activity, the reactivity to pain and the cataleptic response to haloperidol of the mice. However, a significant increase in amphetamine-induced hyperactivity was observed after BCCA. In mice, BCCA did not impair long-term memory and spatial working memory, reflected by alternation behavior in the Y-maze. The same dose of scopolamine impaired the working memory in mice which underwent BCCA much more than sham-operated controls. Naftidrofuryl improved the working memory in mice subjected to BCCA as measured 48 h after the surgery. Pretreatment with naftidrofuryl protected the animals against the impairment of alternation behavior caused by scopolamine administration. FAU - Jozwiak, L AU - Jozwiak L AD - Department of Pharmacology, Medical University, Lublin, Poland. FAU - Sieklucka-Dziuba, M AU - Sieklucka-Dziuba M FAU - Kleinrok, Z AU - Kleinrok Z LA - eng PT - Journal Article PL - Poland TA - Pol J Pharmacol JT - Polish journal of pharmacology JID - 9313882 RN - 42H8PQ0NMJ (Nafronyl) RN - 56-12-2 (gamma-Aminobutyric Acid) RN - DL48G20X8X (Scopolamine) SB - IM MH - Anesthesia MH - Animals MH - Behavior, Animal/*physiology MH - Brain/*blood supply MH - *Brain Chemistry MH - Carotid Arteries/surgery MH - Catalepsy/chemically induced/prevention & control MH - Constriction MH - Frontal Lobe/blood supply/chemistry MH - Hippocampus/blood supply/chemistry MH - Hypoxia/*complications MH - Male MH - Maze Learning/physiology MH - Memory/*physiology MH - Mice MH - Motor Activity/physiology MH - Motor Skills/physiology MH - Nafronyl/pharmacology MH - Pain Measurement MH - Scopolamine/pharmacology MH - Time Factors MH - Visual Cortex/blood supply/chemistry MH - gamma-Aminobutyric Acid/*analysis EDAT- 1999/03/26 00:00 MHDA- 1999/03/26 00:01 CRDT- 1999/03/26 00:00 PHST- 1999/03/26 00:00 [pubmed] PHST- 1999/03/26 00:01 [medline] PHST- 1999/03/26 00:00 [entrez] PST - ppublish SO - Pol J Pharmacol. 1998 Jul-Oct;50(4-5):279-89.