PMID- 10094328
OWN - NLM
STAT- MEDLINE
DCOM- 19990430
LR  - 20151119
IS  - 1027-3719 (Print)
IS  - 1027-3719 (Linking)
VI  - 3
IP  - 3
DP  - 1999 Mar
TI  - The effects of BCG immunization and human immunodeficiency virus infection on 
      dual skin test reactions to purified protein derivative and Mycobacterium avium 
      sensitin among adults in Zambia.
PG  - 255-60
AB  - SETTING: University hospital in Lusaka, Zambia. OBJECTIVE: To determine the 
      effects of childhood bacille Calmette-Guerin (BCG) immunization and human 
      immunodeficiency virus (HIV) infection on dual skin test reactions to purified 
      protein derivative (PPD) and Mycobacterium avium sensitin (MAS) in a developing 
      country. DESIGN: Descriptive cross-sectional study. RESULTS: Dual skin testing 
      was performed on 112 adults, 58 HIV-positive and 54 HIV-negative. Forty-seven 
      (42%) of 112 had PPD reactions > or =10 mm and 52 (46%) had MAS reactions > or 
      =10 mm. PPD reactions > or =10 mm were present in 30 (63%) of 48 BCG-positive 
      subjects compared to 17 (27%) of 64 BCG-negative subjects (P<0.001). Nineteen 
      (33%) of 58 PPD or MAS skin test positive subjects were PPD dominant, 15 (26%) 
      were MAS dominant, and 24 (41%) were non-dominant. MAS dominant and non-dominant 
      reactions were significantly reduced in HIV-positive subjects, and non-dominant 
      reactions were increased in BCG-positive subjects. CONCLUSIONS: Childhood BCG 
      immunization is associated with PPD reactions > or =10 mm among adults. Reduced 
      PPD reaction rates in HIV-positive adults appear to be due to a loss of 
      BCG-induced PPD reactivity. Prior infection with M. avium complex is detectable 
      in a significant proportion of adults in a developing country.
FAU - Waddell, R D
AU  - Waddell RD
AD  - Infectious Disease Section, Dartmouth-Hitchcock Medical Center and Dartmouth 
      Medical School, Lebanon, New Hamshire 03756, USA.
FAU - von Reyn, C F
AU  - von Reyn CF
FAU - Baboo, K S
AU  - Baboo KS
FAU - Mwinga, A
AU  - Mwinga A
FAU - Chintu, C
AU  - Chintu C
FAU - Zumla, A
AU  - Zumla A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal 
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antigens)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (BCG Vaccine)
RN  - 0 (sensitin)
SB  - IM
MH  - Adult
MH  - *Antigens
MH  - *Antigens, Bacterial
MH  - *BCG Vaccine
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/complications
MH  - Humans
MH  - Immunocompromised Host
MH  - Male
MH  - *Tuberculin Test
MH  - Tuberculosis/complications/*diagnosis
MH  - Zambia
EDAT- 1999/03/27 00:00
MHDA- 1999/03/27 00:01
CRDT- 1999/03/27 00:00
PHST- 1999/03/27 00:00 [pubmed]
PHST- 1999/03/27 00:01 [medline]
PHST- 1999/03/27 00:00 [entrez]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 1999 Mar;3(3):255-60.