PMID- 10094375
OWN - NLM
STAT- MEDLINE
DCOM- 19990428
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 37
IP  - 1
DP  - 1999 Jan
TI  - Fecal tumor necrosis factor alpha, eosinophil cationic protein and IgE levels in 
      infants with cow's milk allergy and gastrointestinal manifestations.
PG  - 29-32
AB  - Infants with atopic eczema exhibit a specific fecal protein pattern after oral 
      challenge with cow's milk, characterized by an increase in both eosinophil 
      cationic protein (ECP) and tumor necrosis factor (TNF)alpha. The aim of our study 
      was to determine the pattern of these proteins in allergic infants with 
      intestinal manifestations. TNFalpha, ECP and immunoglobulin E (IgE) were measured 
      in stools from 13 infants with intestinal symptoms and 10 healthy infants. The 
      allergic infants underwent two stool collections, one before a cow's milk 
      challenge and the other after the challenge, either at the onset of clinical 
      manifestations (n=6) or 15 days after the challenge if no clinical manifestations 
      occurred (n=7). Baseline TNFalpha, ECP and IgE levels were low in all infants. 
      The concentration of TNFalpha increased after the challenge in infants positive 
      to challenge (p<0.05) but not in those negative to challenge. ECP and IgE levels 
      remained low after the challenge in all the allergic infants. These data confirm 
      that fecal TNFalpha and ECP levels indicate various reaction types of food 
      allergy and that different immunologic disturbances lead to atopic eczema or 
      intestinal symptoms during food allergy. Fecal protein pattern can thus be a 
      useful tool in diagnosing food allergy in infants with intestinal manifestations.
FAU - Kapel, N
AU  - Kapel N
AD  - Laboratoire de Coprologie Fonctionnelle, Groupe Hospitalier Pitie-Salpetriere, 
      AP-HP, Universite Rene Descartes, Paris, France. 
      nathalie.kapel@psl.ap-hop-paris.fr
FAU - Matarazzo, P
AU  - Matarazzo P
FAU - Haouchine, D
AU  - Haouchine D
FAU - Abiola, N
AU  - Abiola N
FAU - Guerin, S
AU  - Guerin S
FAU - Magne, D
AU  - Magne D
FAU - Gobert, J G
AU  - Gobert JG
FAU - Dupont, C
AU  - Dupont C
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Blood Proteins/*metabolism
MH  - Digestive System/*physiopathology
MH  - Eosinophil Granule Proteins
MH  - Feces/*chemistry
MH  - Humans
MH  - Immunoglobulin E/*metabolism
MH  - Infant
MH  - Milk Hypersensitivity/*metabolism
MH  - *Ribonucleases
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1999/03/27 00:00
MHDA- 1999/03/27 00:01
CRDT- 1999/03/27 00:00
PHST- 1999/03/27 00:00 [pubmed]
PHST- 1999/03/27 00:01 [medline]
PHST- 1999/03/27 00:00 [entrez]
AID - 10.1515/CCLM.1999.004 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 1999 Jan;37(1):29-32. doi: 10.1515/CCLM.1999.004.