PMID- 10094975
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20181201
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 29
IP  - 4
DP  - 1999 Apr
TI  - Human leukocyte antigen class II and III alleles and severity of hepatitis C 
      virus-related chronic liver disease.
PG  - 1272-9
AB  - Hepatitis C outcome is likely related both to viral factors and host's immune 
      responses. We correlated the severity of liver disease with human leukocyte 
      antigen (HLA) genes (C4A, C4B, TNFA, TNFB, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, 
      TAP1, and TAP2) in three groups of subjects: 99 patients with chronic hepatitis, 
      41 asymptomatic carriers, and 179 uninfected controls. Patients with grade/stage 
      3 to 4 hepatitis significantly differentiated for their low frequency of alleles 
      TNFB*1, DRB1*1104, and DRB3*03, which had a protective role, and high frequency 
      of allele DRB1*1001, which was associated with disease severity. HLA-DRB*11 
      subtypes were differentially distributed: DRB1*1104 was most frequent in 
      carriers, whereas DRB1*1101 was more frequent in patients. The TAP1C,2A haplotype 
      was also underrepresented in patients with respect to controls. Finally, a 
      decrease of heterozygous subjects was observed in patients with respect to 
      carriers at the DQB1 locus. Multivariate analysis by correspondence analysis and 
      multiple logistic regression indicated that age, sex, and hepatitis C virus (HCV) 
      type were the strongest risk factors; however, some immunogenetic variables 
      (TNFB*1, DRB1*1104, and DRB3*03) showed an independent contribution, especially 
      in comparing patients with extreme manifestations of disease. The involvement of 
      different genes in various HLA subregions suggests that anti-HCV responses are 
      modulated by a complex gene interplay rather than by single alleles.
FAU - Asti, M
AU  - Asti M
AD  - Department of Pathology, Universita and IRCCS Policlinico San Matteo, Pavia, 
      Italy.
FAU - Martinetti, M
AU  - Martinetti M
FAU - Zavaglia, C
AU  - Zavaglia C
FAU - Cuccia, M C
AU  - Cuccia MC
FAU - Gusberti, L
AU  - Gusberti L
FAU - Tinelli, C
AU  - Tinelli C
FAU - Cividini, A
AU  - Cividini A
FAU - Bruno, S
AU  - Bruno S
FAU - Salvaneschi, L
AU  - Salvaneschi L
FAU - Ideo, G
AU  - Ideo G
FAU - Mondelli, M U
AU  - Mondelli MU
FAU - Silini, E M
AU  - Silini EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA Antigens)
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (TAP1 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 145892-13-3 (TAP2 protein, human)
RN  - 80295-49-4 (Complement C4a)
RN  - 80295-50-7 (Complement C4b)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/genetics
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Cohort Studies
MH  - Complement C4a/genetics
MH  - Complement C4b/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class II/*genetics
MH  - HLA Antigens/*genetics
MH  - Hepatitis C, Chronic/blood/*immunology
MH  - Heterozygote
MH  - Humans
MH  - Lymphotoxin-alpha/genetics
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/genetics
EDAT- 1999/03/30 00:00
MHDA- 1999/03/30 00:01
CRDT- 1999/03/30 00:00
PHST- 1999/03/30 00:00 [pubmed]
PHST- 1999/03/30 00:01 [medline]
PHST- 1999/03/30 00:00 [entrez]
AID - S0270913999001937 [pii]
AID - 10.1002/hep.510290445 [doi]
PST - ppublish
SO  - Hepatology. 1999 Apr;29(4):1272-9. doi: 10.1002/hep.510290445.