PMID- 10095078
OWN - NLM
STAT- MEDLINE
DCOM- 19990513
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 66
IP  - 1-2
DP  - 1999 Mar 20
TI  - Differential effects of GDNF and BDNF on cultured ventral mesencephalic neurons.
PG  - 62-70
AB  - Previous studies have shown that brain derived neurotrophic factor (BDNF) and 
      glial cell line-derived neurotrophic factor (GDNF) can enhance the survival of 
      dopaminergic neurons in the ventral mesencephalon (VM). Here we compared several 
      non-survival functions of the two factors in VM neurons in culture. We found that 
      both BDNF and GDNF elicited an increase in the depolarization-induced release of 
      dopamine, but had no effect on GABA release, in the VM cultures. BDNF, but not 
      GDNF, significantly enhanced the expression of the calcium binding protein 
      calbindin and synaptic protein SNAP25. In contrast, treatment of the cultures 
      with GDNF, but not BDNF, elicited a marked fasciculation of the processes of the 
      VM neurons. Thus, although both act on VM neurons, BDNF and GDNF have distinct 
      functions.
CI  - Copyright 1999 Published by Elsevier Science B.V.
FAU - Feng, L
AU  - Feng L
AD  - Laboratory of Developmental Neurobiology, NICHD, NIH, Bethesda, MD 20892-4480, 
      USA.
FAU - Wang, C Y
AU  - Wang CY
FAU - Jiang, H
AU  - Jiang H
FAU - Oho, C
AU  - Oho C
FAU - Mizuno, K
AU  - Mizuno K
FAU - Dugich-Djordjevic, M
AU  - Dugich-Djordjevic M
FAU - Lu, B
AU  - Lu B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Actins)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calbindins)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (R-SNARE Proteins)
RN  - 0 (S100 Calcium Binding Protein G)
RN  - 0 (Snap25 protein, rat)
RN  - 0 (Synapsins)
RN  - 0 (Synaptosomal-Associated Protein 25)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Actins/biosynthesis
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Calbindins
MH  - Cell Differentiation/drug effects
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Ciliary Neurotrophic Factor
MH  - Dopamine/metabolism
MH  - Fetus/cytology
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Membrane Proteins/biosynthesis
MH  - Mesencephalon/*cytology
MH  - *Nerve Growth Factors
MH  - Nerve Tissue Proteins/biosynthesis/*pharmacology
MH  - Neurons/*cytology/drug effects/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - R-SNARE Proteins
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - S100 Calcium Binding Protein G/biosynthesis
MH  - Synapses/metabolism
MH  - Synapsins/biosynthesis
MH  - Synaptosomal-Associated Protein 25
MH  - gamma-Aminobutyric Acid/metabolism
EDAT- 1999/03/30 00:00
MHDA- 1999/03/30 00:01
CRDT- 1999/03/30 00:00
PHST- 1999/03/30 00:00 [pubmed]
PHST- 1999/03/30 00:01 [medline]
PHST- 1999/03/30 00:00 [entrez]
AID - S0169-328X(99)00015-7 [pii]
AID - 10.1016/s0169-328x(99)00015-7 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):62-70. doi: 
      10.1016/s0169-328x(99)00015-7.