PMID- 10095103 OWN - NLM STAT- MEDLINE DCOM- 19990517 LR - 20190707 IS - 0378-1119 (Print) IS - 0378-1119 (Linking) VI - 229 IP - 1-2 DP - 1999 Mar 18 TI - GEM, a cluster of repetitive sequences in the Drosophila subobscura genome. PG - 47-57 AB - GEM is a new family of repetitive sequences detected in the D. subobscura genome. Two of the four described GEM elements encompass a heterogeneous central module, with no detectable ORF, flanked by two long inverted repeats. These elements are composed of a set of repetitive modules, which are inverted repeat (IR), direct repeat (DR), palindromic sequence (PS), long sequence (LS) and short sequence (SS). These five modules can be found either clustered or dispersed as single modules in the D. subobscura genome, in euchromatic and heterochromatic regions. In addition to the 3' region of Adh retrosequences, single IR and LS blocks were found associated with the promoter region of different genes, in particular, LS-like blocks have also been found associated with functional genes in D. melanogaster and D. virilis. Conversely, the DR block is highly similar to satellite DNAs from some other species of the obscura group. In addition, GEM elements share some structural features with IS elements described in different Drosophila species. It is likely that both GEM and IS sequences would be vestiges of an ancestral transposable element. FAU - Vivas, M V AU - Vivas MV AD - Departamento de Genetica, Facultad de Ciencias Biologicas, Dr. Moliner 50, Burjassot 46100, Valencia, Spain. FAU - Garcia-Planells, J AU - Garcia-Planells J FAU - Ruiz, C AU - Ruiz C FAU - Marfany, G AU - Marfany G FAU - Paricio, N AU - Paricio N FAU - Gonzalez-Duarte, R AU - Gonzalez-Duarte R FAU - de Frutos, R AU - de Frutos R LA - eng SI - GENBANK/AJ131628 SI - GENBANK/AJ131629 PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Netherlands TA - Gene JT - Gene JID - 7706761 RN - 0 (DNA Transposable Elements) RN - EC 1.1.1.1 (Alcohol Dehydrogenase) SB - IM MH - Alcohol Dehydrogenase/genetics MH - Animals MH - Base Sequence MH - Cloning, Molecular MH - DNA Transposable Elements/genetics MH - Drosophila/*genetics MH - Evolution, Molecular MH - *Genes, Insect MH - Genome MH - Molecular Sequence Data MH - Repetitive Sequences, Nucleic Acid/*genetics MH - Sequence Alignment MH - TATA Box/genetics EDAT- 1999/03/30 00:00 MHDA- 1999/03/30 00:01 CRDT- 1999/03/30 00:00 PHST- 1999/03/30 00:00 [pubmed] PHST- 1999/03/30 00:01 [medline] PHST- 1999/03/30 00:00 [entrez] AID - S0378-1119(99)00031-1 [pii] AID - 10.1016/s0378-1119(99)00031-1 [doi] PST - ppublish SO - Gene. 1999 Mar 18;229(1-2):47-57. doi: 10.1016/s0378-1119(99)00031-1.