PMID- 10095859
OWN - NLM
STAT- MEDLINE
DCOM- 19990526
LR  - 20131121
IS  - 0365-5237 (Print)
IS  - 0365-5237 (Linking)
VI  - 539
DP  - 1998
TI  - Effects of trimetaphan-induced deliberate hypotension on human cochlear blood 
      flow.
PG  - 40-3
AB  - In order to observe the reaction of cochlear blood flow (CBF) to trimetaphan 
      (TMP)-induced hypotension, CBF was measured with laser-Doppler flowmetry in 7 
      human subjects during general anaesthesia for middle ear surgery. All subjects 
      showed a decrease in mean arterial pressure (MAP) during intravenous infusion of 
      TMP, followed by a gradual return to the baseline level after termination of the 
      infusion. The CBF generally followed the MAP changes with the same pattern. Three 
      of the seven subjects demonstrated a CBF change larger than the maximum MAP 
      change, indicating the lack of a local autoregulatory mechanism in CBF. On the 
      other hand, CBF changes were smaller in magnitude than the maximum change in MAP 
      for the rest of the subjects, suggesting an autoregulatory mechanism in CBF. 
      However, since the audiograms from these subjects indicated profound damage along 
      the cochlear basal turn probably due to middle ear inflammation, concomitant 
      vascular damage in this region offers another possible explanation for the 
      inappropriate CBF changes. The present observations may also suggest that 
      deliberately TMP-induced hypotension has a potentially harmful effect on CBF 
      during otological surgery that attempts to preserve or improve hearing.
FAU - Tono, T
AU  - Tono T
AD  - Department of Otolaryngology, Miyazaki Medical College, Japan. 
      tono@post1.miyazaki-med.ac.jp
FAU - Ueki, Y
AU  - Ueki Y
FAU - Nagata, N
AU  - Nagata N
FAU - Haruta, A
AU  - Haruta A
FAU - Komune, S
AU  - Komune S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Norway
TA  - Acta Otolaryngol Suppl
JT  - Acta oto-laryngologica. Supplementum
JID - 0370355
RN  - 0 (Ganglionic Blockers)
RN  - 6G8X656T45 (Trimethaphan)
SB  - IM
MH  - Adult
MH  - Anesthesia, General
MH  - Blood Flow Velocity/*drug effects
MH  - Blood Pressure/physiology
MH  - Cochlea/*blood supply/*surgery
MH  - Female
MH  - Ganglionic Blockers/*administration & dosage/adverse effects
MH  - Humans
MH  - Hypotension/*chemically induced
MH  - Laser-Doppler Flowmetry
MH  - Male
MH  - Middle Aged
MH  - Trimethaphan/*administration & dosage/adverse effects
EDAT- 1999/03/30 00:00
MHDA- 1999/03/30 00:01
CRDT- 1999/03/30 00:00
PHST- 1999/03/30 00:00 [pubmed]
PHST- 1999/03/30 00:01 [medline]
PHST- 1999/03/30 00:00 [entrez]
PST - ppublish
SO  - Acta Otolaryngol Suppl. 1998;539:40-3.