PMID- 10096253
OWN - NLM
STAT- MEDLINE
DCOM- 19990401
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 84
IP  - 2
DP  - 1999 Apr 20
TI  - Epidermal growth factor receptor expression in primary laryngeal cancer: an 
      independent prognostic factor of neck node relapse.
PG  - 188-91
AB  - Specimens of laryngeal squamous cell carcinoma (LSCC) were examined for epidermal 
      growth factor receptor (EGFR) content using a radioreceptor method; 140 untreated 
      consecutive patients with primary LSCC undergoing initial surgical resection were 
      followed up for a median of 49 months (range 2-84 months) after surgery. Cox 
      univariate regression analysis using EGFR as a continuous variable showed that 
      EGFR levels were directly associated with the risk of lymph node metastasis. A 
      significant relationship between EGFR status and cervical node metastasis was 
      observed. The cutoff value of 20 fmol/mg protein was the best prognostic 
      discriminator. The 5-year metastasis-free survival (MFS) was 66% for patients 
      with EGFR- tumors compared with 15% for patients with EGFR+ tumors. By 
      multivariate analysis, the EGFR status appeared to be a significant independent 
      prognostic factor for MFS. Our results suggest that the assessment of EGFR status 
      at the time of diagnosis may identify a subset of LSCC patients highly 
      susceptible to neck node metastases thus defining therapy accordingly.
FAU - Almadori, G
AU  - Almadori G
AD  - Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, 
      Italy. iclot@rm.unicat.it
FAU - Cadoni, G
AU  - Cadoni G
FAU - Galli, J
AU  - Galli J
FAU - Ferrandina, G
AU  - Ferrandina G
FAU - Scambia, G
AU  - Scambia G
FAU - Exarchakos, G
AU  - Exarchakos G
FAU - Paludetti, G
AU  - Paludetti G
FAU - Ottaviani, F
AU  - Ottaviani F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Analysis of Variance
MH  - Carcinoma, Squamous Cell/*metabolism/pathology/surgery
MH  - Disease-Free Survival
MH  - ErbB Receptors/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology/surgery
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Neck
MH  - Prognosis
MH  - Regression Analysis
EDAT- 1999/03/30 03:03
MHDA- 2000/06/20 09:00
CRDT- 1999/03/30 03:03
PHST- 1999/03/30 03:03 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/03/30 03:03 [entrez]
AID - 10.1002/(SICI)1097-0215(19990420)84:2<188::AID-IJC16>3.0.CO;2-1 [pii]
AID - 10.1002/(sici)1097-0215(19990420)84:2<188::aid-ijc16>3.0.co;2-1 [doi]
PST - ppublish
SO  - Int J Cancer. 1999 Apr 20;84(2):188-91. doi: 
      10.1002/(sici)1097-0215(19990420)84:2<188::aid-ijc16>3.0.co;2-1.