PMID- 10096576
OWN - NLM
STAT- MEDLINE
DCOM- 19990420
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 20
IP  - 4
DP  - 1999 Apr 1
TI  - Human cyclophilin has a significantly higher affinity for HIV-1 recombinant p55 
      than p24.
PG  - 334-6
AB  - The ability of cyclophilin to bind a panel of recombinant HIV-gag proteins was 
      assessed using sensitive, quantitative, sandwich enzyme-linked immunosorbant 
      assays (ELISAs). Significantly higher binding to cyclophilin was observed when 
      recombinants contained at least 12 carboxy-terminal amino acids of p17 in 
      addition to p24 sequences. These results indicate that the carboxy-terminus of 
      p17 is important for optimal binding of cyclophilin to p24 and support the theory 
      that cyclophilin acts on the uncleaved HIV-1 gag (p17-p24) precursor.
FAU - Bristow, R
AU  - Bristow R
AD  - Murex Biotech Ltd., Dartford, Kent, UK. Richard.Bristow@abbott.com
FAU - Byrne, J
AU  - Byrne J
FAU - Squirell, J
AU  - Squirell J
FAU - Trencher, H
AU  - Trencher H
FAU - Carter, T
AU  - Carter T
FAU - Rodgers, B
AU  - Rodgers B
FAU - Saman, E
AU  - Saman E
FAU - Duncan, J
AU  - Duncan J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
RN  - 0 (Gene Products, gag)
RN  - 0 (HIV Antigens)
RN  - 0 (HIV Core Protein p24)
RN  - 0 (Protein Precursors)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Viral Proteins)
RN  - 0 (gag Gene Products, Human Immunodeficiency Virus)
RN  - 0 (gag protein p26, Human immunodeficiency virus)
RN  - 0 (p17 protein, Human Immunodeficiency Virus Type 1)
RN  - 0 (p55 gag precursor protein, Human immunodeficiency virus 1)
RN  - EC 5.2.1.8 (Peptidylprolyl Isomerase)
SB  - IM
MH  - Gene Products, gag/genetics/*metabolism
MH  - HIV Antigens/genetics/metabolism
MH  - HIV Core Protein p24/genetics/*metabolism
MH  - HIV-1/genetics/*metabolism
MH  - Humans
MH  - Peptidylprolyl Isomerase/*metabolism
MH  - Protein Precursors/genetics/*metabolism
MH  - Recombinant Fusion Proteins/genetics/metabolism
MH  - *Viral Proteins
MH  - gag Gene Products, Human Immunodeficiency Virus
EDAT- 1999/03/30 00:00
MHDA- 1999/03/30 00:01
CRDT- 1999/03/30 00:00
PHST- 1999/03/30 00:00 [pubmed]
PHST- 1999/03/30 00:01 [medline]
PHST- 1999/03/30 00:00 [entrez]
AID - 10.1097/00042560-199904010-00002 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):334-6. doi: 
      10.1097/00042560-199904010-00002.