PMID- 100967 OWN - NLM STAT- MEDLINE DCOM- 19781227 LR - 20161123 IS - 0042-8809 (Print) IS - 0042-8809 (Linking) VI - 24 IP - 5 DP - 1978 Sep-Oct TI - [Relationship between aminoglucuronide synthesis in the bodies of white rats and the physico-chemical properties of the substrate]. PG - 676-8 AB - In rats 5-substituted 2-aminobenzophenones (R-NH2; CH3; Cl) formed N-glucuronides. Amounts of free substances and of the glucuronyl-conjugates, excreted with the urine, depended on the nature of the radical; the derivatives differed in the values of Hammet's constants, in the lipophility and alkalinity. Estimation of Hammet's constants enabled to find a satisfactory correlation between the physico-chemical properties of the derivatives studied and the amounts of glucuronides excreted with urine. FAU - Golovenko, N Ia AU - Golovenko NIa LA - rus PT - Comparative Study PT - Journal Article TT - Sintez aminogliukuronidov v organizme belykh krys zavisimost' protsessa ot fiziko-khimicheskikh svoistv substrata. PL - Russia (Federation) TA - Vopr Med Khim JT - Voprosy meditsinskoi khimii JID - 0416601 RN - 0 (Benzophenones) RN - 0 (Glucuronates) RN - EC 2.4.1.17 (Glucuronosyltransferase) SB - IM MH - Animals MH - Benzophenones/*metabolism MH - Chemical Phenomena MH - Chemistry, Physical MH - Glucuronates/*biosynthesis MH - Glucuronosyltransferase/*metabolism MH - Male MH - Rats MH - Structure-Activity Relationship EDAT- 1978/09/01 00:00 MHDA- 1978/09/01 00:01 CRDT- 1978/09/01 00:00 PHST- 1978/09/01 00:00 [pubmed] PHST- 1978/09/01 00:01 [medline] PHST- 1978/09/01 00:00 [entrez] PST - ppublish SO - Vopr Med Khim. 1978 Sep-Oct;24(5):676-8.