PMID- 10099112
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20081121
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 179 Suppl 3
DP  - 1999 May
TI  - Mucosal dendritic cells and immunodeficiency viruses.
PG  - S427-30
AB  - Dendritic cells [DCs] have been implicated in the pathogenesis of human 
      immunodeficiency virus type 1 (HIV-1). When skin was used as a model for mucosae, 
      the cutaneous DC-T cell milieu allowed the growth of HIV-1 and much of the newly 
      produced virus could be detected in multinucleated DC-T cell syncytia. Such virus 
      replication occurs irrespective of the genetic subtype, the syncytium- and 
      non-syncytium-inducing capacities of the viruses, and whether they are classified 
      as T cell- or macrophage-tropic. Similar DC-syncytia have been identified within 
      the mucosal surfaces of the tonsillar tissue of HIV-1-infected persons. More 
      recently, it was demonstrated that DC-T cell mixtures from the skin, mucosae, and 
      blood of healthy macaques similarly support the replication of simian 
      immunodeficiency virus. In both the human and monkey systems, active virus 
      replication requires the presence of both DCs and T cells. Further studies using 
      the macaque model are underway to elucidate the role of DCs in the transmission 
      and spread of HIV infection.
FAU - Pope, M
AU  - Pope M
AD  - Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New 
      York, NY 10021, USA. popem@rockvax.rockefeller.edu
LA  - eng
GR  - AI-36082/AI/NIAID NIH HHS/United States
GR  - AI-40045/AI/NIAID NIH HHS/United States
GR  - AI-40874/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
MH  - Animals
MH  - Dendritic Cells/immunology/*virology
MH  - HIV-1/immunology/*pathogenicity/physiology
MH  - Humans
MH  - Macaca
MH  - Mouth Mucosa/immunology/virology
MH  - Palatine Tonsil/immunology/virology
MH  - T-Lymphocytes/immunology/virology
MH  - Virus Replication
RF  - 24
EDAT- 1999/04/01 03:08
MHDA- 2000/03/21 09:00
CRDT- 1999/04/01 03:08
PHST- 1999/04/01 03:08 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/04/01 03:08 [entrez]
AID - JID980258 [pii]
AID - 10.1086/314798 [doi]
PST - ppublish
SO  - J Infect Dis. 1999 May;179 Suppl 3:S427-30. doi: 10.1086/314798.