PMID- 10100194
OWN - NLM
STAT- MEDLINE
DCOM- 19990521
LR  - 20190831
IS  - 0197-0186 (Print)
IS  - 0197-0186 (Linking)
VI  - 34
IP  - 1
DP  - 1999 Jan
TI  - Acute effects of 3,4-methylenedioxymethamphetamine on brain serotonin synthesis 
      in the dog studied by positron emission tomography.
PG  - 33-40
AB  - The influence of an acute dose (2 mg/kg; i.v.; infused over 10 min) of 
      3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) on the brain serotonin 
      synthesis in the dog was assessed using alpha [11C]methyl-L-tryptophan and 
      positron emission tomography. The rate of serotonin synthesis measured 1 h after 
      injection of MDMA was six times greater than the base line (before MDMA) 
      synthesis. Five hours after the MDMA injection, serotonin synthesis was about one 
      half that at the base line, and about one thirteenth of the synthesis at 1 h 
      after MDMA. A large increase seen 1 h after MDMA probably relates to the large 
      release of serotonin by MDMA and reflects an attempt of the serotonergic system 
      to replenish released serotonin. This probably correlates with the mood changes 
      reported by humans after MDMA intake. Decrease observed 5 h after MDMA, in part, 
      probably relates to the inhibitory effects of the released serotonin, which could 
      act on the activity of tryptophan hydroxylase directly or indirectly via other 
      monoaminergic systems (e.g. dopaminergic).
FAU - Nishisawa, S
AU  - Nishisawa S
AD  - Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill 
      University, Quebec, Canada.
FAU - Mzengeza, S
AU  - Mzengeza S
FAU - Diksic, M
AU  - Diksic M
LA  - eng
GR  - R01-NS-29629/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 8DUH1N11BX (Tryptophan)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier
MH  - Brain/*drug effects/metabolism
MH  - Dogs
MH  - Kinetics
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Serotonin/*biosynthesis
MH  - Serotonin Agents/*pharmacology
MH  - *Tomography, Emission-Computed
MH  - Tryptophan/blood
EDAT- 1999/04/01 00:00
MHDA- 1999/04/01 00:01
CRDT- 1999/04/01 00:00
PHST- 1999/04/01 00:00 [pubmed]
PHST- 1999/04/01 00:01 [medline]
PHST- 1999/04/01 00:00 [entrez]
AID - S0197-0186(98)00067-9 [pii]
AID - 10.1016/s0197-0186(98)00067-9 [doi]
PST - ppublish
SO  - Neurochem Int. 1999 Jan;34(1):33-40. doi: 10.1016/s0197-0186(98)00067-9.