PMID- 10102737
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20131121
IS  - 0095-6562 (Print)
IS  - 0095-6562 (Linking)
VI  - 70
IP  - 3 Pt 1
DP  - 1999 Mar
TI  - Plasma amino acids during human spaceflight.
PG  - 250-5
AB  - BACKGROUND: The plasma amino acid distribution patterns were measured before, 
      during and after flight on the Space Shuttle. The plasma samples were collected 
      from the four payload crewmembers of the 1993 SLS-2 Columbia Shuttle mission. 
      Samples were taken 45, 15 and 8 d before flight; inflight on days 2, 8 and 12 
      after launch; post-flight on the day of landing; and again 6, 14 and 45 d after 
      landing. RESULTS: Most of the changes found pertained to the essential amino 
      acids, particularly the branched chain amino acids (BCAA). The principle findings 
      were: a) The plasma aminograms for inflight days 8 and 12 were very similar and 
      both aminograms were very different from that of flight day 2. Flight day 2 was 
      not different from the preflight ground control. b) With increasing time in 
      space, there was an increase in the concentration of leucine and isoleucine in 
      the plasma (p < 0.05). This increase occurred even though dietary BCAA intake was 
      not increased inflight. c) The concentrations of the total essential amino acids 
      and the branched chain amino acids (BCAA) in particular were decreased on the day 
      of landing (p < 0.05).
FAU - Stein, T P
AU  - Stein TP
AD  - Department of Surgery, University of Medicine and Dentistry of New Jersey, School 
      of Osteopathic Medicine, Stratford 08084, USA.
FAU - Schluter, M D
AU  - Schluter MD
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Aviat Space Environ Med
JT  - Aviation, space, and environmental medicine
JID - 7501714
RN  - 0 (Amino Acids)
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 04Y7590D77 (Isoleucine)
RN  - GMW67QNF9C (Leucine)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Amino Acids/*blood
MH  - Amino Acids, Branched-Chain/blood
MH  - Diet
MH  - Energy Intake
MH  - Humans
MH  - Isoleucine/blood
MH  - Leucine/blood
MH  - Nitrogen/metabolism
MH  - *Space Flight
OTO - NASA
OT  - NASA Discipline Regulatory Physiology
OT  - NASA Experiment Number 178120 2/2
OT  - Non-NASA Center
SFM - Flight Experiment
SFM - STS-58 Shuttle Project
SFM - manned
SFM - short duration
FIR - Stein, T P
IR  - Stein TP
IRAD- U Med Dent NJ, Stratford
FIR - Schluter, M D
IR  - Schluter MD
IRAD- U Med Dent NJ, Stratford
EDAT- 1999/04/02 00:00
MHDA- 1999/04/02 00:01
CRDT- 1999/04/02 00:00
PHST- 1999/04/02 00:00 [pubmed]
PHST- 1999/04/02 00:01 [medline]
PHST- 1999/04/02 00:00 [entrez]
PST - ppublish
SO  - Aviat Space Environ Med. 1999 Mar;70(3 Pt 1):250-5.