PMID- 10149136
OWN - NLM
STAT- MEDLINE
DCOM- 19920625
LR  - 20191103
IS  - 0267-6605 (Print)
IS  - 0267-6605 (Linking)
VI  - 7
IP  - 3
DP  - 1991
TI  - Methods for improving drug release from poly(methyl)methacrylate bone cement.
PG  - 227-31
AB  - Poly(methylmethacrylate) (PMMA) is a widely used material with both dental and 
      orthopaedic applications. The acrylic cement is produced by the combination of 
      polymethylacrylate beads with methylmethacrylate monomer. After polymerisation, a 
      heterogeneous and porous matrix is formed which can be used to deliver 
      therapeutic agents. In this work, the release of antibiotic, growth hormone and 
      serum albumin is demonstrated. The mechanism is similar for all agents; a rapid 
      release followed by a slow continuous release. The quantity of drug released 
      depends upon the formulation of both the PMMA and the drug. The 
      polymer-to-monomer ratio can greatly affect the ratio of drug release; increased 
      polymer-to-monomer ratio leads to increased release of antibiotic. Optimum 
      release is achieved if a crystalline formulation of the drug is used rather than 
      a fine powder. Experimental methods to improve the drug release performance of 
      bone cements are presented.
FAU - Downes, S
AU  - Downes S
AD  - Institute of Orthopaedics, Stanmore, Middlesex, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Mater
JT  - Clinical materials
JID - 8707278
RN  - 0 (Bone Cements)
RN  - 0 (Gentamicins)
RN  - 0 (Methylmethacrylates)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 9002-72-6 (Growth Hormone)
MH  - *Bone Cements/chemistry
MH  - Drug Delivery Systems
MH  - Gentamicins/chemistry
MH  - Growth Hormone/chemistry
MH  - Humans
MH  - Methylmethacrylates/chemistry
MH  - Serum Albumin, Bovine/chemistry
EDAT- 1990/12/10 00:00
MHDA- 1990/12/10 00:01
CRDT- 1990/12/10 00:00
PHST- 1990/12/10 00:00 [pubmed]
PHST- 1990/12/10 00:01 [medline]
PHST- 1990/12/10 00:00 [entrez]
AID - 10.1016/0267-6605(91)90063-l [doi]
PST - ppublish
SO  - Clin Mater. 1991;7(3):227-31. doi: 10.1016/0267-6605(91)90063-l.