PMID- 1015669 OWN - NLM STAT- MEDLINE DCOM- 19770315 LR - 20151119 IS - 0003-3898 (Print) IS - 0003-3898 (Linking) VI - 34 IP - 5 DP - 1976 TI - [Proposal of a new procedure for the exploration of hepatocellular function. The trimethoxybenzene test (TMB)]. PG - 323-8 AB - The authors propose a new method of exploration of liver cell function based on the study of demethylation of a rapidly assimilated atoxic compound, trimethoxybenzene (TMB) in dimethoxy-hydroxybenzene (DMHB). Whereas in normal subjects, the urinary excretion of the metabolites was rapid and marked, 180 mg within 3 hours after taking a 400 mg dose, in patients with liver cell failure, the excretion of DMHB was considerably reduced, 80 to 95% in cirrhosis. FAU - Rousselet, F AU - Rousselet F FAU - Fredj, G AU - Fredj G FAU - Clenet, M AU - Clenet M LA - fre PT - English Abstract PT - Journal Article TT - Proposition d'un nouveau procede d'exploration de la fonction hepatocellulaire. Le "test au trimethoxybenzene" (TMB). PL - France TA - Ann Biol Clin (Paris) JT - Annales de biologie clinique JID - 2984690R RN - 0 (Benzene Derivatives) SB - IM MH - *Benzene Derivatives/metabolism MH - Humans MH - Liver Cirrhosis/diagnosis MH - Liver Function Tests/*methods EDAT- 1976/01/01 00:00 MHDA- 1976/01/01 00:01 CRDT- 1976/01/01 00:00 PHST- 1976/01/01 00:00 [pubmed] PHST- 1976/01/01 00:01 [medline] PHST- 1976/01/01 00:00 [entrez] PST - ppublish SO - Ann Biol Clin (Paris). 1976;34(5):323-8.