PMID- 10174695
OWN - NLM
STAT- MEDLINE
DCOM- 19980114
LR  - 20191103
IS  - 0955-3886 (Print)
IS  - 0955-3886 (Linking)
VI  - 18
IP  - 2
DP  - 1997 Jun
TI  - Dendritic cells: therapeutic potentials.
PG  - 313-26
AB  - Dendritic cells (DCs) are leukocytes that are specialized to capture antigens and 
      initiate T-cell-mediated immune responses. After capture of antigens, DCs, then 
      in an immature stage, leave their tissue of residence and migrate through the 
      lymph/blood into secondary lymphoid organs where they differentiate into mature 
      cells. Because DCs can prime animals in the absence of any other adjuvant, they 
      have been termed 'nature's adjuvant'. Large numbers of DCs can now be generated 
      from circulating monocytes or from CD34 hematopoietic progenitors in response to 
      GM-CSF in combination with either IL4 or TNF alpha. In mice, tumor antigen loaded 
      DCs have been shown to prevent the development of tumors and even to induce the 
      regression of established tumors. DCs therapy represents a very promising 
      approach to the treatment of cancer and infectious diseases. Early studies 
      indicate the existence of DC populations that can induce tolerance and may prove 
      useful in organ transplantation.
FAU - Banchereau, J
AU  - Banchereau J
AD  - Schering-Plough, Laboratory for Immunological Research, Dardilly, France.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Transfus Sci
JT  - Transfusion science
JID - 9001514
MH  - Animals
MH  - Cell Separation
MH  - Cell- and Tissue-Based Therapy
MH  - Dendritic Cells/*immunology/*transplantation
MH  - Humans
MH  - *Immune Tolerance
MH  - Mice
MH  - *Organ Transplantation
RF  - 87
EDAT- 1997/05/07 00:00
MHDA- 1997/05/07 00:01
CRDT- 1997/05/07 00:00
PHST- 1997/05/07 00:00 [pubmed]
PHST- 1997/05/07 00:01 [medline]
PHST- 1997/05/07 00:00 [entrez]
AID - S0955-3886(97)00022-2 [pii]
AID - 10.1016/s0955-3886(97)00022-2 [doi]
PST - ppublish
SO  - Transfus Sci. 1997 Jun;18(2):313-26. doi: 10.1016/s0955-3886(97)00022-2.