PMID- 10190687
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20191103
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 5
IP  - 1
DP  - 1999 Feb
TI  - Chemokines and peripheral nerve demyelination.
PG  - 27-31
AB  - It has been speculated that beta-chemokines play a pivotal role in the 
      development of peripheral nervous system (PNS) disorders characterized by 
      mononuclear cell infiltration. In experimental allergic neuritis (EAN), an animal 
      model for human Guillain-Barre syndrome (GBS) with mononuclear cell infiltration, 
      we found by quantitative PCR that beta-chemokine messages were upregulated during 
      the active stage. Moreover, an increase in the monocyte chemoattractant protein-1 
      (MCP-1) message was found in the preclinical stage of EAN, suggesting the 
      critical role of MCP-1 for inducing mononuclear cell infiltrations in this model. 
      Since many cell lineages other than immune cells can produce chemokines, this 
      early upregulation of MCP-1 may be mediated by non-immune cells, probably 
      endothelia or Schwann cells. To date, apart from MCP-1, only RANTES (Regulated on 
      activation, normal T cell expressed and secreted) and macrophage inflammatory 
      protein (MIP)-1alpha have been examined in EAN and found to have similar kinetics 
      of induction. Therefore, understanding the regulation of production of these 
      chemokines as well as mechanisms of inhibiting chemokine/receptor interactions in 
      the PNS may ultimately lead to disease-specific therapy for GBS and related 
      demyelinating disorders.
FAU - Fujioka, T
AU  - Fujioka T
AD  - Department of Neurology, University of Pennsylvania Medical School, Philadelphia 
      19104, USA.
FAU - Kolson, D L
AU  - Kolson DL
FAU - Rostami, A M
AU  - Rostami AM
LA  - eng
GR  - NS-11037/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CC)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/metabolism
MH  - Chemokines/genetics/*metabolism
MH  - Chemokines, CC/metabolism
MH  - Demyelinating Diseases/*etiology/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Neuritis, Autoimmune, Experimental/*metabolism
MH  - Peripheral Nervous System Diseases/*etiology/metabolism
MH  - Polyradiculoneuropathy/etiology/metabolism
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Schwann Cells/metabolism
MH  - Time Factors
MH  - Up-Regulation/physiology
RF  - 40
EDAT- 1999/04/06 00:00
MHDA- 1999/04/06 00:01
CRDT- 1999/04/06 00:00
PHST- 1999/04/06 00:00 [pubmed]
PHST- 1999/04/06 00:01 [medline]
PHST- 1999/04/06 00:00 [entrez]
AID - 10.3109/13550289909029742 [doi]
PST - ppublish
SO  - J Neurovirol. 1999 Feb;5(1):27-31. doi: 10.3109/13550289909029742.