PMID- 10191207
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20041117
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 179
IP  - 5
DP  - 1999 May
TI  - Association of major histocompatibility complex determinants with the development 
      of symptomatic and asymptomatic genital herpes simplex virus type 2 infections.
PG  - 1077-85
AB  - The clinical spectrum of herpes simplex virus (HSV) infections, ranging from 
      asymptomatic to frequently distressing outbreaks, suggests that there may be 
      immunologic determinants of disease severity that are associated with human 
      leukocyte antigen (HLA) expression. A controlled, prospective study identified 
      several major histocompatibility complex (MHC) class I and II antigens whose 
      frequencies are associated with HSV-2 infection or with frequent symptomatic 
      genital recurrences. Previous studies were hampered by the inability to 
      serologically identify patients with asymptomatic HSV-2 infection. Clinical 
      evaluation and Western blot assay were used to identify 3 subject cohorts: 1 with 
      no prior HSV infections, 1 with HSV-2 antibodies but no recognized symptoms, and 
      1 with HSV-2 antibodies and frequent genital recurrences. Statistical comparisons 
      of HLA frequencies among these cohorts showed associations of HLA-B27 and -Cw2 
      with symptomatic disease. Also, HLA-Cw4 was significantly associated with HSV-2 
      infection. These associations indicate that immunologic factors linked to the MHC 
      influence the risk of HSV-2 infection and disease expression.
FAU - Lekstrom-Himes, J A
AU  - Lekstrom-Himes JA
AD  - Medical Virology Section, Laboratory of Clinical Investigation, National 
      Institute of Allergy and Infectious Diseases, National Institutes of Health, 
      Bethesda, MD 20892, USA. juliel@nhgri.nih.gov
FAU - Hohman, P
AU  - Hohman P
FAU - Warren, T
AU  - Warren T
FAU - Wald, A
AU  - Wald A
FAU - Nam, J M
AU  - Nam JM
FAU - Simonis, T
AU  - Simonis T
FAU - Corey, L
AU  - Corey L
FAU - Straus, S E
AU  - Straus SE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Antibodies, Viral/blood
MH  - Blotting, Western
MH  - Cohort Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - HLA Antigens/*genetics
MH  - HLA-B27 Antigen/genetics
MH  - HLA-C Antigens/genetics
MH  - Herpes Genitalis/*immunology/pathology/virology
MH  - Herpesvirus 2, Human/immunology
MH  - Humans
MH  - Male
MH  - Prospective Studies
EDAT- 1999/04/07 02:00
MHDA- 2000/03/21 09:00
CRDT- 1999/04/07 02:00
PHST- 1999/04/07 02:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/04/07 02:00 [entrez]
AID - JID981116 [pii]
AID - 10.1086/314729 [doi]
PST - ppublish
SO  - J Infect Dis. 1999 May;179(5):1077-85. doi: 10.1086/314729.