PMID- 10191320
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20191023
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 8
DP  - 1999 Apr 15
TI  - A changing pattern of brain-derived neurotrophic factor expression correlates 
      with the rearrangement of fibers during cochlear development of rats and mice.
PG  - 3033-42
AB  - The reorganization of specific neuronal connections is a typical feature of the 
      developing nervous system. It is assumed that the refinement of connections in 
      sensory systems requires spontaneous activity before the onset of cochlear 
      function and selective sensory experience during the ensuing period. The 
      mechanism of refinement through sensory experience is currently postulated as 
      being based on the selective reinforcement of active projections by 
      neurotrophins. We studied a presumed role of neurotrophins for rearrangement of 
      afferent and efferent fibers before the onset of sensory function in the 
      precisely innervated auditory end organ, the cochlea. We observed a 
      spatiotemporal change in the localization of brain-derived neurotrophic factor 
      (BDNF) protein and mRNA, which correlated with the reorganization of fibers. 
      Thus, BDNF decreased in target hair cells during fiber retraction and was 
      subsequently upregulated in neurons, target hair cells, and adjacent supporting 
      cells concomitant with the formation of new synaptic contacts. Analysis of the 
      innervation pattern in BDNF gene-deleted mice by immunohistochemistry and 
      confocal microscopy revealed a failure in the rearrangement of fibers and a BDNF 
      dependency of distinct neuronal projections that reorganize in control animals. 
      Our data suggest that, before the onset of auditory function, a spatiotemporal 
      change in BDNF expression in sensory, epithelial, and neuronal cells may guide 
      the initial steps of refinement of the innervation pattern.
FAU - Wiechers, B
AU  - Wiechers B
AD  - Department of Oto-Rhino-Laryngology, University of Tubingen, D-72076 Tubingen, 
      Germany.
FAU - Gestwa, G
AU  - Gestwa G
FAU - Mack, A
AU  - Mack A
FAU - Carroll, P
AU  - Carroll P
FAU - Zenner, H P
AU  - Zenner HP
FAU - Knipper, M
AU  - Knipper M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Afferent Pathways/physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cochlea/growth & development/*metabolism
MH  - Efferent Pathways/physiology
MH  - Hair Cells, Auditory, Outer/metabolism
MH  - Immunohistochemistry
MH  - Mice
MH  - Mice, Knockout
MH  - Nerve Fibers/*metabolism
MH  - Presynaptic Terminals/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
PMC - PMC6782279
EDAT- 1999/04/07 00:00
MHDA- 1999/04/07 00:01
PMCR- 1999/10/15
CRDT- 1999/04/07 00:00
PHST- 1999/04/07 00:00 [pubmed]
PHST- 1999/04/07 00:01 [medline]
PHST- 1999/04/07 00:00 [entrez]
PHST- 1999/10/15 00:00 [pmc-release]
AID - 2944 [pii]
AID - 10.1523/JNEUROSCI.19-08-03033.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Apr 15;19(8):3033-42. doi: 10.1523/JNEUROSCI.19-08-03033.1999.