PMID- 10192434
OWN - NLM
STAT- MEDLINE
DCOM- 19990618
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 104
IP  - 4
DP  - 1999 Mar
TI  - The sequential analysis of trisomy 12 in B-cell chronic lymphocytic leukaemia.
PG  - 742-4
AB  - In this longitudinal study we evaluated the clinical significance of screening 
      for trisomy 12 by fluorescence in situ hybridization (FISH) and correlated these 
      findings with survival, disease progression and need for treatment. Interphase 
      FISH was performed on 85 patients in 1993/94 and repeated on 41 patients in 
      1996/97. Over the 4-year period there was no significant change in the percentage 
      of trisomic cells, even in patients with disease progression. Overall survival 
      and requirement for treatment were similar for patients with and without 
      FISH-defined trisomy 12.
FAU - Auer, R L
AU  - Auer RL
AD  - Department of Haematology, Birmingham Heartlands Hospital, Bordesley Green East.
FAU - Bienz, N
AU  - Bienz N
FAU - Neilson, J
AU  - Neilson J
FAU - Cai, M
AU  - Cai M
FAU - Waters, J J
AU  - Waters JJ
FAU - Milligan, D W
AU  - Milligan DW
FAU - Fegan, C D
AU  - Fegan CD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Longitudinal Studies
MH  - *Trisomy
EDAT- 1999/04/07 00:00
MHDA- 1999/04/07 00:01
CRDT- 1999/04/07 00:00
PHST- 1999/04/07 00:00 [pubmed]
PHST- 1999/04/07 00:01 [medline]
PHST- 1999/04/07 00:00 [entrez]
AID - 10.1046/j.1365-2141.1999.01259.x [doi]
PST - ppublish
SO  - Br J Haematol. 1999 Mar;104(4):742-4. doi: 10.1046/j.1365-2141.1999.01259.x.