PMID- 10192566
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20061115
IS  - 1102-4151 (Print)
IS  - 1102-4151 (Linking)
VI  - 165
IP  - 2
DP  - 1999 Feb
TI  - The cytokines IL-1beta and IL-1 receptor antagonist, IL-2 and IL-2 soluble 
      receptor-alpha, IL-6 and IL-6 soluble receptor, TNF-alpha and TNF soluble 
      receptor I, and IL10 in drained and systemic blood after major orthopaedic 
      surgery.
PG  - 101-9
AB  - OBJECTIVE: To measure the concentration of the cytokines interleukin-1beta 
      (IL-1beta), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), 
      and tumour necrosis factor-alpha (TNF-alpha) and the modulators of their function 
      interleukin-1 receptor antagonist (IL-1Ra), interleukin-2 soluble receptor alpha 
      (IL-2 sRalpha), interleukin-6 soluble receptor (IL-6sR) and soluble tumour 
      necrosis factor receptor I (sTNFR-I) in systemic and drained blood for the first 
      six hours after a major orthopaedic operation. DESIGN: Prospective study. 
      SETTING: University hospital, Oslo. PATIENTS: 8 patients operated on for thoracic 
      scoliosis. MAIN OUTCOME MEASURE: Concentrations of IL-1beta, IL-2, IL-6, IL-10, 
      TNF-alpha, IL-1Ra, IL-2 sRalpha , IL-6sR, and sTNFR-I were measured together with 
      haemoglobin (Hb) concentration, white cell count (WCC), and differential count in 
      arterial and drained blood at wound closure and 1, 2, 4, and 6 hours 
      postoperatively. RESULTS: IL-1beta and IL-6 concentrations increased 
      significantly in drained blood, whereas that of TNF-alpha increased only in 
      arterial blood. The modulating factors IL-1Ra, sTNFR-I, and IL-10 were increased 
      both in arterial and drained blood. IL-6sR had decreased slightly at 6 hours in 
      drained blood. No IL-2 was found and IL-2 sRalpha decreased simultaneously with 
      the haemodilution. In arterial blood there was a granulocytosis and in drained 
      blood a relative lymphocytosis. CONCLUSION: Cytokine responses to surgical trauma 
      include modulating factors such as soluble receptors and receptor antagonists 
      that have different responses systemically and locally.
FAU - Krohn, C D
AU  - Krohn CD
AD  - Centre for Orthopaedics, National Hospital, Trondhjemsveien, Oslo, Norway.
FAU - Reikeras, O
AU  - Reikeras O
FAU - Aasen, A O
AU  - Aasen AO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Surg
JT  - The European journal of surgery = Acta chirurgica
JID - 9105264
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukins)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Receptors, Interleukin-6)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - Interleukin-1/blood
MH  - Interleukin-10/blood
MH  - Interleukin-2/blood
MH  - Interleukin-6/blood
MH  - Interleukins/*blood
MH  - Male
MH  - *Orthopedic Procedures
MH  - *Receptors, Interleukin
MH  - Receptors, Interleukin-1/antagonists & inhibitors
MH  - Receptors, Interleukin-6/blood
MH  - Receptors, Tumor Necrosis Factor/blood
MH  - Scoliosis/blood/surgery
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1999/04/07 00:00
MHDA- 1999/04/07 00:01
CRDT- 1999/04/07 00:00
PHST- 1999/04/07 00:00 [pubmed]
PHST- 1999/04/07 00:01 [medline]
PHST- 1999/04/07 00:00 [entrez]
AID - 10.1080/110241599750007261 [doi]
PST - ppublish
SO  - Eur J Surg. 1999 Feb;165(2):101-9. doi: 10.1080/110241599750007261.