PMID- 10192710
OWN - NLM
STAT- MEDLINE
DCOM- 19990504
LR  - 20190831
IS  - 0934-9723 (Print)
IS  - 0934-9723 (Linking)
VI  - 18
IP  - 1
DP  - 1999 Jan
TI  - Randomised study of the possible adjuvant effect of BCG vaccine on the 
      immunogenicity of diphtheria-tetanus-acellular pertussis vaccine in Senegalese 
      infants.
PG  - 23-9
AB  - Following a study in Senegal (1990-1995) in which the relative efficacy of a 
      diphtheria-tetanus-acellular pertussis vaccine (DTaP) was compared with that of a 
      diphtheria-tetanus-whole-cell pertussis vaccine in children given a simultaneous 
      injection of Bacille Calmette-Guerin (BCG) vaccine, this subsequent study was 
      conducted to evaluate the possible adjuvant effect of the BCG vaccine on 
      acellular pertussis vaccine components. A second objective was to compare the 
      immunogenicity of these components when administered in accordance with a 
      2-4-6-month (spaced) schedule or an accelerated 2-3-4-month schedule. In all, 390 
      healthy Senegalese infants were randomly divided into three groups of 130 
      infants. Antibodies to acellular pertussis components were measured in serum 
      samples obtained within 2 days of the first DTaP dose and 1 month after the third 
      dose. BCG vaccine, given simultaneously with the DTaP vaccine, did not influence 
      the immunogenicity of the acellular pertussis vaccine components when compared 
      with separate administration of the two vaccines. Infants immunised according to 
      a 2-4-6-month schedule had a significantly higher immune response than those 
      immunised according to a 2-3-4-month schedule with respect to the response to 
      pertussis toxoid assessed by seroneutralisation on Chinese hamster ovary cells 
      (P<0.0001). These results suggest that BCG and DTaP vaccines can be given 
      simultaneously without interference or enhancement and that more optimal 
      immunogenicity is achieved with an extended than with an accelerated schedule.
FAU - Simondon, F
AU  - Simondon F
AD  - Unite de Recherche sur les Maladies Infectieuses et Parasitaires, Institut 
      Francais de Recherche Scientifique pour le Developpement en Cooperation (ORSTOM), 
      Montpellier. Francois.Simondon@mpl.orstom.fr
FAU - Preziosi, M P
AU  - Preziosi MP
FAU - Pinchinat, S
AU  - Pinchinat S
FAU - Yam, A
AU  - Yam A
FAU - Chabirand, L
AU  - Chabirand L
FAU - Wassilak, S
AU  - Wassilak S
FAU - Pines, E
AU  - Pines E
FAU - Trape, J F
AU  - Trape JF
FAU - Salomon, H
AU  - Salomon H
FAU - Hoffenbach, A
AU  - Hoffenbach A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official 
      publication of the European Society of Clinical Microbiology
JID - 8804297
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (BCG Vaccine)
RN  - 0 (Diphtheria-Tetanus-Pertussis Vaccine)
RN  - 0 (Diphtheria-Tetanus-acellular Pertussis Vaccines)
RN  - 0 (Toxoids)
RN  - 0 (pertussis toxoid)
SB  - IM
MH  - Antibodies, Bacterial/*biosynthesis
MH  - BCG Vaccine/administration & dosage/*immunology
MH  - Bordetella pertussis/*immunology
MH  - Diphtheria-Tetanus-Pertussis Vaccine/administration & dosage/*immunology
MH  - Diphtheria-Tetanus-acellular Pertussis Vaccines
MH  - Humans
MH  - Immunization Schedule
MH  - Infant
MH  - Malaria/immunology
MH  - Senegal
MH  - Toxoids/immunology
EDAT- 1999/04/07 00:00
MHDA- 1999/04/07 00:01
CRDT- 1999/04/07 00:00
PHST- 1999/04/07 00:00 [pubmed]
PHST- 1999/04/07 00:01 [medline]
PHST- 1999/04/07 00:00 [entrez]
AID - 10.1007/s100960050221 [doi]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 1999 Jan;18(1):23-9. doi: 10.1007/s100960050221.