PMID- 10192913
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20031114
IS  - 0916-8451 (Print)
IS  - 0916-8451 (Linking)
VI  - 63
IP  - 2
DP  - 1999 Feb
TI  - Effects of various kinds of dietary amino acids on the hepatotoxic action of 
      D-galactosamine in rats.
PG  - 319-22
AB  - The protective effects of various kinds of dietary amino acids against the 
      hepatotoxic action of D-galactosamine (GalN) were examined. Male Wistar rats fed 
      with 20% casein diets containing 10% or 5% amino acid for one week were injected 
      with GalN (800 mg/kg body weight), and the serum aspartate aminotransferase 
      (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) 
      activities, the hepatic glycogen concentration, and the serum glucose-level were 
      examined 20 hours after the injection. In the groups with the 10% amino acid 
      diets, activities of AST, ALT, and LDH in serum of 10% L-glutamine (Gln), 10% 
      L-asparagine (Asn), and 10% L-serine (Ser) groups were significantly lower than 
      those of the control group, and in the groups with the 5% amino acid diets, those 
      activities of 5% L-histidine (His), 5% L-tyrosine (Tyr), 5% L-lysine (Lys), and 
      5% L-glycine (Gly) groups were also lower than those of the control group. The 
      concentration of liver glycogen of 10% Gln-, 10% Asn-, and 10% Ser- groups and 
      those levels of 5% His-, 5% Tyr-, 5% Lys-, and 5% Gly-groups were also 
      significantly higher than that of the control group. As a result, it was found 
      that some kinds of dietary amino acid such as L-Ser, L-Asn, L-His, L-Lys, L-Tyr, 
      and L-Gly, in addition to L-Gln were effective to protect the rats from 
      GalN-induced injury.
FAU - Wang, B
AU  - Wang B
AD  - Graduate School of Science and Technology, Chiba University, Japan.
FAU - Ishihara, M
AU  - Ishihara M
FAU - Egashira, Y
AU  - Egashira Y
FAU - Ohta, T
AU  - Ohta T
FAU - Sanada, H
AU  - Sanada H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Caseins)
RN  - 7535-00-4 (Galactosamine)
RN  - 9005-79-2 (Glycogen)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Amino Acids/*metabolism
MH  - Animals
MH  - Aspartate Aminotransferases/blood
MH  - Blood Glucose/analysis
MH  - Body Weight
MH  - Caseins/metabolism
MH  - Eating
MH  - Galactosamine/*metabolism
MH  - Glycogen/analysis
MH  - Hepatitis, Animal/*prevention & control
MH  - L-Lactate Dehydrogenase/blood
MH  - Liver/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
EDAT- 1999/04/08 00:00
MHDA- 1999/04/08 00:01
CRDT- 1999/04/08 00:00
PHST- 1999/04/08 00:00 [pubmed]
PHST- 1999/04/08 00:01 [medline]
PHST- 1999/04/08 00:00 [entrez]
AID - 10.1271/bbb.63.319 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 1999 Feb;63(2):319-22. doi: 10.1271/bbb.63.319.