PMID- 10192916
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20131121
IS  - 0916-8451 (Print)
IS  - 0916-8451 (Linking)
VI  - 63
IP  - 2
DP  - 1999 Feb
TI  - Decrease in the levels of NGF and BDNF in brains of mice fed a 
      tryptophan-deficient diet.
PG  - 337-40
AB  - The roles of dietary tryptophan (Trp) were evaluated in regulation of production 
      of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and 
      neurotrophin (NT)-3 in the various brain regions in ddY mice. Feeding the mice a 
      Trp-deficient diet for 2 weeks significantly decreased in the hippocampal level 
      of NGF but not those of BDNF and NT-3, as compared with feeding an adequate Trp 
      diet. The mice fed excess Trp did not have different levels of any of these 
      neurotrophins than in the mice fed an adequate Trp diet. The levels of BDNF in 
      the cerebral cortex were also significantly lower in the mice fed on a 
      Trp-deficient diet, while the levels of NGF and NT-3 in the region were not 
      modulated upon feeding of the diet. The dietary Trp level had no significant 
      effect on the levels of NGF, BDNF, or NT-3 in the entorhinal cortex nor septum of 
      the mice. These results demonstrate that the brain levels of NGF and BDNF are 
      dependent on the dietary content of tryptophan.
FAU - Lee, D R
AU  - Lee DR
AD  - Nagoya University Bioscience Center, Japan.
FAU - Semba, R
AU  - Semba R
FAU - Kondo, H
AU  - Kondo H
FAU - Goto, S
AU  - Goto S
FAU - Nakano, K
AU  - Nakano K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - Alzheimer Disease/metabolism
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/analysis/*biosynthesis
MH  - Cerebral Cortex/metabolism
MH  - Entorhinal Cortex/metabolism
MH  - Hippocampus/metabolism
MH  - Male
MH  - Mice
MH  - Nerve Growth Factors/analysis/*biosynthesis
MH  - Neurotrophin 3
MH  - Septum Pellucidum/metabolism
MH  - Tryptophan/*deficiency/metabolism
EDAT- 1999/04/08 00:00
MHDA- 1999/04/08 00:01
CRDT- 1999/04/08 00:00
PHST- 1999/04/08 00:00 [pubmed]
PHST- 1999/04/08 00:01 [medline]
PHST- 1999/04/08 00:00 [entrez]
AID - 10.1271/bbb.63.337 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 1999 Feb;63(2):337-40. doi: 10.1271/bbb.63.337.